14-3-3 proteins bind AKT-phosphorylated FOXO3

Stable Identifier
R-HSA-9614562
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Nuclear exclusion and cytoplasmic retention of AKT-phosphorylated FOXO3 is promoted by binding of FOXO3 to 14-3-3 proteins: YWHAZ (14-3-3 zeta), YWHAQ (14-3-3 theta), and SFN (14-3-3 sigma) (Brunet et al. 1999, Arimoto-Ishida et al. 2004).

Literature References
PubMed ID Title Journal Year
14701673 Inhibition of phosphorylation of a forkhead transcription factor sensitizes human ovarian cancer cells to cisplatin

Arimoto-Ishida, E, Ohmichi, M, Mabuchi, S, Takahashi, T, Ohshima, C, Hayakawa, J, Kimura, A, Takahashi, K, Nishio, Y, Sakata, M, Kurachi, H, Tasaka, K, Murata, Y

Endocrinology 2004
10102273 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Brunet, A, Bonni, A, Zigmond, MJ, Lin, MZ, Juo, P, Hu, LS, Anderson, MJ, Arden, KC, Blenis, J, Greenberg, ME

Cell 1999
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created