14-3-3 proteins bind AKT-phosphorylated FOXO3

Stable Identifier
Reaction [binding]
Homo sapiens
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Nuclear exclusion and cytoplasmic retention of AKT-phosphorylated FOXO3 is promoted by binding of FOXO3 to 14-3-3 proteins: YWHAZ (14-3-3 zeta), YWHAQ (14-3-3 theta), and SFN (14-3-3 sigma) (Brunet et al. 1999, Arimoto-Ishida et al. 2004).

Literature References
PubMed ID Title Journal Year
14701673 Inhibition of phosphorylation of a forkhead transcription factor sensitizes human ovarian cancer cells to cisplatin

Arimoto-Ishida, E, Ohmichi, M, Mabuchi, S, Takahashi, T, Ohshima, C, Hayakawa, J, Kimura, A, Takahashi, K, Nishio, Y, Sakata, M, Kurachi, H, Tasaka, K, Murata, Y

Endocrinology 2004
10102273 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Brunet, A, Bonni, A, Zigmond, MJ, Lin, MZ, Juo, P, Hu, LS, Anderson, MJ, Arden, KC, Blenis, J, Greenberg, ME

Cell 1999
Participant Of
Orthologous Events
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