Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs

Stable Identifier
R-HSA-9614343
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
cytosol
ReviewStatus
5/5
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Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs
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Tegument proteins help deliver the Human Cytomegalovirus (HCMV) genome-containing capsid to the nucleus during the viral entry process. Signals initiated upon receptor binding induce cellular antiviral responses but may also prime the cell for subsequent events during viral entry. The Capsid-associated tegument proteins UL47 and UL48 (and perhaps pp150) direct capsids along microtubules (MTs) toward nuclear pore complexes driven by cellular motor proteins such as dynein.
Literature References
PubMed ID Title Journal Year
18203656 Entry route of HCMV into endothelial cells

Sinzger, C

J. Clin. Virol. 2008
  Fields Virology

Knipe, DM, Howley, PM

  2013
12857923 Microtubule network facilitates nuclear targeting of human cytomegalovirus capsid

Ogawa-Goto, K, Tanaka, K, Gibson, W, Moriishi, E, Miura, Y, Kurata, T, Irie, S, Sata, T

J. Virol. 2003
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
transport of viral material towards nucleus (0075606)
Catalyst Activity

microtubule binding activity of HCMV Tegumented Virion [viral tegument]

Physical Entity
HCMV Tegumented Virion [viral tegument] (Human cytomegalovirus)
Activity
microtubule binding (GO:0008017)
Disease
Name Identifier Synonyms
viral infectious disease DOID:934 Viral disease, virus infection, virus infection
Cross References
Mondo
Authored
Gillespie, ME  (2018-06-20)
Reviewed
Caposio, P  (2019-10-18)
Streblow, DN  (2019-10-18)
Created
Gillespie, ME  (2018-07-24)
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