Reactome | ADGRG heterodimer translocates to plasma membrane

ADGRG heterodimer translocates to plasma membrane

Stable Identifier

R-HSA-9614273

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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ADGRG heterodimer translocates to plasma membrane

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Mature ADGRG6 is expressed at the plasma membrane as a non-covalently associated heterodimer of the N- and C terminal fragments (Moriguchi et al, 2004; Arac et al, 2012; reviewed in Langenhan et al, 2013; Mehta et al, 2017). In addition to cleavage at the GPS site, ADGRG6 may additionally be cleaved in the trans-Golgi network by a furin-like protease at an S2 site upstream of the GPS site. This cleavage yields a soluble N-terminal-most subfragment that may have roles in non cell autonomous signaling or contribute to regulation of ADGRG6 activation/inactivation (Moriguchi et al, 2004; reviewed in Langenhan et al, 2013).

Literature References

PubMed ID	Title	Journal	Year
23695165	Sticky signaling--adhesion class G protein-coupled receptors take the stage Langenhan, T, Hamann, J, Aust, G	Sci Signal	2013
22333914	A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis Boucard, AA, Bolliger, MF, Südhof, TC, Nguyen, J, Araç, D, Soltis, SM, Brunger, AT	EMBO J.	2012
27859941	Adhesion G-protein coupled receptors and extracellular matrix proteins: Roles in myelination and glial cell development Piao, X, Mehta, P	Dev. Dyn.	2017
15189448	DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites Moriguchi, T, Okada, M, Haraguchi, K, Furuya, T, Akiyama, T, Ueda, N	Genes Cells	2004