Mature ADGRG6 is expressed at the plasma membrane as a non-covalently associated heterodimer of the N- and C terminal fragments (Moriguchi et al, 2004; Arac et al, 2012; reviewed in Langenhan et al, 2013; Mehta et al, 2017). In addition to cleavage at the GPS site, ADGRG6 may additionally be cleaved in the trans-Golgi network by a furin-like protease at an S2 site upstream of the GPS site. This cleavage yields a soluble N-terminal-most subfragment that may have roles in non cell autonomous signaling or contribute to regulation of ADGRG6 activation/inactivation (Moriguchi et al, 2004; reviewed in Langenhan et al, 2013).
Langenhan, T, Hamann, J, Aust, G
Boucard, AA, Bolliger, MF, Südhof, TC, Nguyen, J, Araç, D, Soltis, SM, Brunger, AT
Piao, X, Mehta, P
Moriguchi, T, Okada, M, Haraguchi, K, Furuya, T, Akiyama, T, Ueda, N
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