Reactome | Autocleavage of ADGRG6

Autocleavage of ADGRG6

Stable Identifier

R-HSA-9614271

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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ADGRG6, also known as GPR126, is a member of the adhesion class of G-protein coupled receptors (aGPCRs). aGPCRs are characterized by a 7 transmembrane-spanning domain that couples to G-protein signaling and an extracellular N-terminal extension that mediates cell-cell or cell-matrix adhesion (reviewed in Langenhan et al, 2013). Like most aGPCRs, ADGRG6 is subject to autocatalytic processing during maturation, yielding a C-terminal fragment containing the 7-TM region, and an N-terminal fragment containing the extracellular region. Cleavage occurs at the conserved GPCR proteolytic site (GPS), part of the larger GPCR autoproteolysis-inducing (GAIN) domain (Moriguchi et al, 2004; Arac et al, 2012). As with other aGPCRs, these two domains remain associated in a heterodimer at the plasma membrane where they mediate signaling and cell adhesion (Moriguchi et al 2004; Arac et al, 2012; Lin et al, 2004; reviewed in Langenhan et al, 2013; Mehta et al, 2017).

Literature References

PubMed ID	Title	Journal	Year
22333914	A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis Araç, D, Boucard, AA, Bolliger, MF, Nguyen, J, Soltis, SM, Südhof, TC, Brunger, AT	EMBO J.	2012
23695165	Sticky signaling--adhesion class G protein-coupled receptors take the stage Langenhan, T, Aust, G, Hamann, J	Sci Signal	2013
27859941	Adhesion G-protein coupled receptors and extracellular matrix proteins: Roles in myelination and glial cell development Mehta, P, Piao, X	Dev. Dyn.	2017
15189448	DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites Moriguchi, T, Haraguchi, K, Ueda, N, Okada, M, Furuya, T, Akiyama, T	Genes Cells	2004
15150276	Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif Lin, HH, Chang, GW, Davies, JQ, Stacey, M, Harris, J, Gordon, S	J. Biol. Chem.	2004