Reactome | Autocleavage of ADGRG6

Autocleavage of ADGRG6

Stable Identifier

R-HSA-9614271

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ADGRG6, also known as GPR126, is a member of the adhesion class of G-protein coupled receptors (aGPCRs). aGPCRs are characterized by a 7 transmembrane-spanning domain that couples to G-protein signaling and an extracellular N-terminal extension that mediates cell-cell or cell-matrix adhesion (reviewed in Langenhan et al, 2013). Like most aGPCRs, ADGRG6 is subject to autocatalytic processing during maturation, yielding a C-terminal fragment containing the 7-TM region, and an N-terminal fragment containing the extracellular region. Cleavage occurs at the conserved GPCR proteolytic site (GPS), part of the larger GPCR autoproteolysis-inducing (GAIN) domain (Moriguchi et al, 2004; Arac et al, 2012). As with other aGPCRs, these two domains remain associated in a heterodimer at the plasma membrane where they mediate signaling and cell adhesion (Moriguchi et al 2004; Arac et al, 2012; Lin et al, 2004; reviewed in Langenhan et al, 2013; Mehta et al, 2017).

Literature References

PubMed ID	Title	Journal	Year
22333914	A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis Boucard, AA, Bolliger, MF, Südhof, TC, Nguyen, J, Araç, D, Soltis, SM, Brunger, AT	EMBO J.	2012
23695165	Sticky signaling--adhesion class G protein-coupled receptors take the stage Langenhan, T, Hamann, J, Aust, G	Sci Signal	2013
27859941	Adhesion G-protein coupled receptors and extracellular matrix proteins: Roles in myelination and glial cell development Piao, X, Mehta, P	Dev. Dyn.	2017
15189448	DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites Moriguchi, T, Okada, M, Haraguchi, K, Furuya, T, Akiyama, T, Ueda, N	Genes Cells	2004
15150276	Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif Gordon, S, Lin, HH, Davies, JQ, Stacey, M, Chang, GW, Harris, J	J. Biol. Chem.	2004