During the process of peripheral nerve myelination, EGR2 expression is controlled by a feedforward transcriptional program initiated by SOX10 and maintained by POU3F2, PU3F1 and EGR2 itself (reviewed in Svaren and Meijer, 2008). Expression of EGR2 during the myelination process is controlled by a myelinating Schwann cell enhancer (MSE) 35 kb downstream of the gene (Ghislain et al, 2002). The MSE is bound by SOX10, POU3F1 and POU3F2 (Ghislain and Charnay, 2006; Reiprich et al, 2010). SOX10 in turn recruits SMARCA4, HDAC1 and HDAC2 to play overlapping but non-redundant roles in activating EGR2 expression (Jacob et al, 2011; Chen et al, 2011; Weider et al, 2012).
Weider, M, Küspert, M, Bischof, M, Vogl, MR, Hornig, J, Loy, K, Kosian, T, Müller, J, Hillgärtner, S, Tamm, ER, Metzger, D, Wegner, M
Jacob, C, Christen, CN, Pereira, JA, Somandin, C, Baggiolini, A, Lötscher, P, Ozçelik, M, Tricaud, N, Meijer, D, Yamaguchi, T, Matthias, P, Suter, U
Chen, Y, Wang, H, Yoon, SO, Xu, X, Hottiger, MO, Svaren, J, Nave, KA, Kim, HA, Olson, EN, Lu, QR
Svaren, J, Meijer, D
Reiprich, S, Kriesch, J, Schreiner, S, Wegner, M
Ghislain, J, Charnay, P
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