SOX10, POU3F1 and POU3F2 bind EGR2 gene

Stable Identifier
R-HSA-9613768
Type
Reaction [binding]
Species
Homo sapiens
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During the process of peripheral nerve myelination, EGR2 expression is controlled by a feedforward transcriptional program initiated by SOX10 and maintained by POU3F2, PU3F1 and EGR2 itself (reviewed in Svaren and Meijer, 2008). Expression of EGR2 during the myelination process is controlled by a myelinating Schwann cell enhancer (MSE) 35 kb downstream of the gene (Ghislain et al, 2002). The MSE is bound by SOX10, POU3F1 and POU3F2 (Ghislain and Charnay, 2006; Reiprich et al, 2010). SOX10 in turn recruits SMARCA4, HDAC1 and HDAC2 to play overlapping but non-redundant roles in activating EGR2 expression (Jacob et al, 2011; Chen et al, 2011; Weider et al, 2012).

Literature References
PubMed ID Title Journal Year
22814607 Chromatin-remodeling factor Brg1 is required for Schwann cell differentiation and myelination

Weider, M, Küspert, M, Bischof, M, Vogl, MR, Hornig, J, Loy, K, Kosian, T, Müller, J, Hillgärtner, S, Tamm, ER, Metzger, D, Wegner, M

Dev. Cell 2012
21423190 HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells

Jacob, C, Christen, CN, Pereira, JA, Somandin, C, Baggiolini, A, Lötscher, P, Ozçelik, M, Tricaud, N, Meijer, D, Yamaguchi, T, Matthias, P, Suter, U

Nat. Neurosci. 2011
21423191 HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination

Chen, Y, Wang, H, Yoon, SO, Xu, X, Hottiger, MO, Svaren, J, Nave, KA, Kim, HA, Olson, EN, Lu, QR

Nat. Neurosci. 2011
18803322 The molecular machinery of myelin gene transcription in Schwann cells

Svaren, J, Meijer, D

Glia 2008
19922439 Activation of Krox20 gene expression by Sox10 in myelinating Schwann cells

Reiprich, S, Kriesch, J, Schreiner, S, Wegner, M

J. Neurochem. 2010
16311519 Control of myelination in Schwann cells: a Krox20 cis-regulatory element integrates Oct6, Brn2 and Sox10 activities

Ghislain, J, Charnay, P

EMBO Rep. 2006
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