During the process of peripheral nerve myelination, EGR2 expression is controlled by a feedforward transcriptional program initiated by SOX10 and maintained by POU3F2, PU3F1 and EGR2 itself (reviewed in Svaren and Meijer, 2008). Expression of EGR2 during the myelination process is controlled by a myelinating Schwann cell enhancer (MSE) 35 kb downstream of the gene (Ghislain et al, 2002). The MSE is bound by SOX10, POU3F1 and POU3F2 (Ghislain and Charnay, 2006; Reiprich et al, 2010). SOX10 in turn recruits SMARCA4, HDAC1 and HDAC2 to play overlapping but non-redundant roles in activating EGR2 expression (Jacob et al, 2011; Chen et al, 2011; Weider et al, 2012).
Yamaguchi, T, Meijer, D, Pereira, JA, Jacob, C, Suter, U, Tricaud, N, Baggiolini, A, Matthias, P, Somandin, C, Lötscher, P, Ozçelik, M, Christen, CN
Kosian, T, Küspert, M, Wegner, M, Weider, M, Müller, J, Hornig, J, Hillgärtner, S, Vogl, MR, Metzger, D, Bischof, M, Tamm, ER, Loy, K
Xu, X, Lu, QR, Hottiger, MO, Nave, KA, Wang, H, Yoon, SO, Kim, HA, Olson, EN, Svaren, J, Chen, Y
Meijer, D, Svaren, J
Wegner, M, Kriesch, J, Reiprich, S, Schreiner, S
Ghislain, J, Charnay, P
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