Reactome | p-PLIN2 [cytosol]

p-PLIN2 [cytosol]

Stable Identifier

R-HSA-9613667

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Locations in the PathwayBrowser

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Autophagy (Homo sapiens)

- Chaperone Mediated Autophagy (Homo sapiens)
  - GFAP binds LAMP2a multimer (Homo sapiens)
    - LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
      - Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
    - LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
      - LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
  - HSPA8 binds substrate (Homo sapiens)
    - HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
      - Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
    - Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
      - Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
  - HSPA8 dissociates from LAMP2A-bound substrate (Homo sapiens)
    - HSPA8:Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
      - HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
    - Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
      - Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
  - HSPA8 transports unfolded substrate to lysosomal lumen for degradation (Homo sapiens)
    - HSPA8:LAMP2a multimeric complex [lysosomal membrane] (Homo sapiens)
      - LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
        
        LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
  - HSPA8:Substrate binds LAMP2a (Homo sapiens)
    - HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
      - Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
    - HSPA8:Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
      - HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
  - Substrate:LAMP2a binds HSP90 (Homo sapiens)
    - Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
      - Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
    - Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
      - Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
  - Substrate:LAMP2a:HSP90 polymerizes (Homo sapiens)
    - LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
      - Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
    - Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
      - Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
  - Unfolded substrate in LAMP2a multimeric complex binds HSPA8 (Homo sapiens)
    - HSPA8:LAMP2a multimeric complex [lysosomal membrane] (Homo sapiens)
      - LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
        
        LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
    - LAMP2a multimer complex:GFAP [lysosomal membrane] (Homo sapiens)
      - LAMP2a multimer complex [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a:HSP90 [lysosomal membrane] (Homo sapiens)
        
        Substrate:LAMP2a [lysosomal membrane] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
- Late endosomal microautophagy (Homo sapiens)
  - HSPA8 binds substrate (Homo sapiens)
    - HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
      - Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
    - Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
      - Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
  - HSPA8:substrate binds late endosomal phospholipids (Homo sapiens)
    - HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
      - Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
    - PL:HSPA8:Autophagy substrate [late endosome membrane] (Homo sapiens)
      - HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
  - Substrate translocates into late endosomal lumen (Homo sapiens)
    - PL:HSPA8:Autophagy substrate [late endosome membrane] (Homo sapiens)
      - HSPA8 bound autophagic substrates [cytosol] (Homo sapiens)
        
        Substrates for chaperone mediated autophagy [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)
- Macroautophagy (Homo sapiens)
  - Selective autophagy (Homo sapiens)
    - Lipophagy (Homo sapiens)
      - p-PLINs translocate from lipid droplet surface to cytosol (Homo sapiens)
        
        p-PLINs:HSPA8 [cytosol] (Homo sapiens)
        
        Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)
        
        p-PLIN2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99541 PLIN2

Gene Names

PLIN2, ADFP

Chain

initiator methionine:, chain:2-437

Reference Genes

BioGPS Gene:123 PLIN2

COSMIC (genes):PLIN2 PLIN2

CTD Gene:123 PLIN2

dbSNP Gene:123 PLIN2

ENSEMBL:ENSG00000147872 PLIN2

HGNC:248 PLIN2

KEGG:hsa:123 PLIN2

Monarch:123 PLIN2

NCBI Gene:123 PLIN2

OMIM:103195 PLIN2

UCSC:Q99541 PLIN2

Reference Transcript

RefSeq:NM_001122.3 PLIN2

Other Identifiers

11742745_a_at

11742746_a_at

123

209122_PM_at

209122_at

2436251

2436254

3200649

3200652

3200653

3200654

3200655

3200656

3200657

3200660

3200661

3200662

3200664

3200665

3200666

3200667

3200668

3200669

3200670

3200671

3200675

3200676

3200677

3200678

3200679

3200680

3200681

3200684

34378_at

8160297

A_21_P0014779

A_23_P134953

A_33_P3258617

GE60192

GE874376

GO:0005515

GO:0005576

GO:0005634

GO:0005737

GO:0005783

GO:0005811

GO:0005829

GO:0005886

GO:0009410

GO:0010890

GO:0014070

GO:0015909

GO:0016020

GO:0019915

GO:0042149

GO:0043226

GO:1905691

HMNXSV003010946

HMNXSV003011922

HMNXSV003041052

HMNXSV003041772

ILMN_1801077

ILMN_2138765

PH_hs_0000411

TC09000935.hg

TC09002418.hg

TC09002419.hg

X97324_at

g13477306_3p_at

Participates

as a member of

Phosphorylated PLINs from lipid droplet surface [cytosol] (Homo sapiens)

Other forms of this molecule

PLIN2 [plasma membrane]

p-PLIN2 [late endosome lumen]

PLIN2 [lipid droplet]

p-PLIN2 [lipid droplet]

p-PLIN2 [lysosomal lumen]

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_001113.2

ENSEMBL

ENST00000276914, ENSP00000276914

OpenTargets

ENSG00000147872

HPA

ENSG00000147872-PLIN2

PRO

Q99541

Pharos - Targets

Q99541

GlyGen

Q99541

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9BUP3-3 HTATIP2			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:Q7Z3K3 POGZ			0.556	3
UniProt:O95562 SFT2B			0.556	3
UniProt:Q9BSY9 DESI2			0.556	3
UniProt:Q8WTS1 ABHD5	2	ABHD5 [lipid droplet] (R-HSA-163485) ABHD5 [cytosol] (R-HSA-163531)	0.556	3
UniProt:P0DTD8 NS7B			0.547	2

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