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PRKAA2 dissociate from p-PLINs:HSPA8
Stable Identifier
R-HSA-9613565
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
,
lipid droplet
ReviewStatus
5/5
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PRKAA2 dissociate from p-PLINs:HSPA8 (Homo sapiens)
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Once phosphorylated, PLINs are believed to dissociate from PRKAA2 and translocate to the cytosol (S Kaushik et al. 2015, S Kaushik et al. 2016). The precise dissociation mechanism of Plins is unclear. The experiments showing this finding were performed in mouse models.
Literature References
PubMed ID
Title
Journal
Year
26902588
AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA
Cuervo, AM
,
Kaushik, S
Autophagy
2016
25961502
Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis
Cuervo, AM
,
Kaushik, S
Nat. Cell Biol.
2015
Participants
Input
p-PLINs:HSPA8:PRKAA2 [lipid droplet]
(Homo sapiens)
Output
p-PLINs:HSPA8 [lipid droplet]
(Homo sapiens)
PRKAA2 [cytosol]
(Homo sapiens)
Participates
as an event of
Lipophagy (Homo sapiens)
Inferred From
Prkaa2 dissociate from p-Plins:Hspa8 (Mus musculus)
Authored
Varusai, TM (2019-02-21)
Reviewed
Metzakopian, E (2019-02-22)
Created
Varusai, TM (2018-07-16)
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