Unwinding DNA for the nascent transcript

Stable Identifier
Reaction [uncertain]
Homo sapiens
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The human BTF2 basic transcription factor (also called TFIIH), is required for class1 gene transcription of transcripts. TFIIH has an adenosine triphosphate-dependent DNA helicase activity. The helicase activity is closely associated with the multi-subunit BTF2/TFIIH transcription factor which also has a CTD protein kinase activity.

Literature References
PubMed ID Title Journal Year
11784853 Translocation after synthesis of a four-nucleotide RNA commits RNA polymerase II to promoter escape.

Goodrich, JA, Kugel, JF

Mol Cell Biol 2002
8465201 DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor

Chambon, P, Roy, R, Hoeijmakers, JH, Egly, JM, Schaeffer, L, Humbert, S, Vermeulen, W, Moncollin, V

Science 1993
9405375 Three transitions in the RNA polymerase II transcription complex during initiation.

Fiedler, U, Timmers, HT, Holstege, FC

EMBO J 1998
Catalyst Activity

3'-5' DNA helicase activity of TFIIH [nucleoplasm]

Orthologous Events
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