EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions

Stable Identifier
R-HSA-9613476
Type
Reaction [binding]
Species
Homo sapiens
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EGR2 is required for peripheral nerve cell myelination in Schwann cells where it activates some target genes and represses others (Topilko et al, 1999; Zorick et al, 1996; Le et al, 2005; Le Blanc et al, 2005). ID2 and ID4 were identified as targets of EGR2-mediated repression during peripheral nerve myelination (Mager et al, 2008). EGR2 represses ID2 and ID4 gene expression by recruiting NAB2 and the NURD chromatin remodelling complex (Mager et al, 2008, Srinivasan et al, 2006).

Literature References
PubMed ID Title Journal Year
8918830 The transcription factors SCIP and Krox-20 mark distinct stages and cell fates in Schwann cell differentiation

Zorick, TS, Syroid, DE, Arroyo, E, Scherer, SS, Lemke, G

Mol. Cell. Neurosci. 1996
16136673 Nab proteins are essential for peripheral nervous system myelination

Le, N, Nagarajan, R, Wang, JY, Svaren, J, LaPash, C, Araki, T, Schmidt, RE, Milbrandt, J

Nat. Neurosci. 2005
16574654 NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex

Srinivasan, R, Mager, GM, Ward, RM, Mayer, J, Svaren, J

J. Biol. Chem. 2006
18456662 Active gene repression by the Egr2.NAB complex during peripheral nerve myelination

Mager, GM, Ward, RM, Srinivasan, R, Jang, SW, Wrabetz, L, Svaren, J

J. Biol. Chem. 2008
15836632 Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination

Leblanc, SE, Srinivasan, R, Ferri, C, Mager, GM, Gillian-Daniel, AL, Wrabetz, L, Svaren, J

J. Neurochem. 2005
10656257 Reciprocal Id expression and myelin gene regulation in Schwann cells

Thatikunta, P, Qin, W, Christy, BA, Tennekoon, GI, Rutkowski, JL

Mol. Cell. Neurosci. 1999
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