p-S133 CREB1, LYL1 and EP300 bind the ID1 and ID3 genes

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CREB1, EP300 and LYL1 are required for the activation of the ID1 and ID3 genes, which contribute to cellular proliferation and differentiation (Impey et al, 2004; San Marina et al, 2008; Rivera and Murre, 2001; Hong et al, 2011; Zhao et al, 2016). CREB1 binds to the CRE elements in the ID gene promoters and recruits EP300 in a CREB1 S133 phosphorylation dependent manner. S133 phosphorylation is dispensable for recruitment of LYL1, which instead depends on an interaction between the LYL1 N-terminal domain and the Q2 and KID domains of CREB1 (San Marina et al, 2008).

Literature References
PubMed ID Title Journal Year
21486943 ID1 and ID3 represent conserved negative regulators of human embryonic and induced pluripotent stem cell hematopoiesis

Bhatia, M, Hong, SH, Ji, J, Lee, JB, Lee, JH

J. Cell. Sci. 2011
18160048 Lyl1 interacts with CREB1 and alters expression of CREB1 target genes

San-Marina, S, Suarez Saiz, F, Trus, MR, Minden, MD, Han, Y

Biochim. Biophys. Acta 2008
27128622 Combined Id1 and Id3 Deletion Leads to Severe Erythropoietic Disturbances

Zhao, Q, Gonzalez, JP, Chang, C, Button, JL, Fraidenraich, D, Alzahrani, K

PLoS ONE 2016
15620361 Defining the CREB regulon: a genome-wide analysis of transcription factor regulatory regions

Impey, S, Mandel, G, Dwyer, JM, McCorkle, SR, Yochum, GS, McWeeney, S, Goodman, RH, Cha-Molstad, H, Boss, JM, Dunn, JJ

Cell 2004
11840323 The regulation and function of the Id proteins in lymphocyte development

Murre, C, Rivera, R

Oncogene 2001
Cite Us!