CREB1, EP300 and LYL1 are required for the activation of the ID1 and ID3 genes, which contribute to cellular proliferation and differentiation (Impey et al, 2004; San Marina et al, 2008; Rivera and Murre, 2001; Hong et al, 2011; Zhao et al, 2016). CREB1 binds to the CRE elements in the ID gene promoters and recruits EP300 in a CREB1 S133 phosphorylation dependent manner. S133 phosphorylation is dispensable for recruitment of LYL1, which instead depends on an interaction between the LYL1 N-terminal domain and the Q2 and KID domains of CREB1 (San Marina et al, 2008).
Bhatia, M, Hong, SH, Ji, J, Lee, JB, Lee, JH
San-Marina, S, Suarez Saiz, F, Trus, MR, Minden, MD, Han, Y
Zhao, Q, Gonzalez, JP, Chang, C, Button, JL, Fraidenraich, D, Alzahrani, K
Impey, S, Mandel, G, Dwyer, JM, McCorkle, SR, Yochum, GS, McWeeney, S, Goodman, RH, Cha-Molstad, H, Boss, JM, Dunn, JJ
Murre, C, Rivera, R
© 2022 Reactome