EGR1, EGR2 bind the RRAD promoter

Stable Identifier
R-HSA-9613210
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
EGR1, EGR2 bind the RRAD promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

EGR1 and EGR2 are required for the activation of RRAD gene expression (Mager et al, 2008; Svaren et al, 2000). RRAD protein plays a role in serum-stimulated DNA synthesis in melanoma cells and contributes to electrical conductance in the heart (Zhu et al, 1999; Wang et al, 2010; Chang et al, 2007).

Literature References
PubMed ID Title Journal Year
18456662 Active gene repression by the Egr2.NAB complex during peripheral nerve myelination

Wrabetz, L, Mager, GM, Ward, RM, Svaren, J, Jang, SW, Srinivasan, R

J. Biol. Chem. 2008
10984481 EGR1 target genes in prostate carcinoma cells identified by microarray analysis

Watson, MA, Milbrandt, J, Ehrengruber, MU, Abdulkadir, SA, Svaren, J, Ehrig, T

J. Biol. Chem. 2000
10611312 Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation

Kahn, CR, Zhu, J, Moyers, JS, Tseng, YH, Kantor, JD, Zetter, BR, Rhodes, CJ

Proc. Natl. Acad. Sci. U.S.A. 1999
19926875 Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart

Chen, C, Cheng, H, Wu, C, Wang, G, Song, R, Han, P, Cao, C, Xie, W, Li, K, Sun, Z, Zhu, X, Liu, J, Zhang, J, Wang, Y

Circ. Res. 2010
18056528 Rad GTPase deficiency leads to cardiac hypertrophy

Kahn, CR, Tseng, YH, Chang, L, Chen, YE, Ilany, J, Yang, Q, Cui, T, Sun, Z, Brüning, JC, Day, SM, Zhu, X, Xie, CQ, Youker, KA, Zhang, J

Circulation 2007
Participants
Input
Output
Participates
as an event of
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-07-12)
Cite Us!