EGR1, EGR2 bind the RRAD promoter

Stable Identifier
Reaction [transition]
Homo sapiens
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EGR1 and EGR2 are required for the activation of RRAD gene expression (Mager et al, 2008; Svaren et al, 2000). RRAD protein plays a role in serum-stimulated DNA synthesis in melanoma cells and contributes to electrical conductance in the heart (Zhu et al, 1999; Wang et al, 2010; Chang et al, 2007).

Literature References
PubMed ID Title Journal Year
10984481 EGR1 target genes in prostate carcinoma cells identified by microarray analysis

Svaren, J, Ehrig, T, Abdulkadir, SA, Ehrengruber, MU, Watson, MA, Milbrandt, J

J. Biol. Chem. 2000
18456662 Active gene repression by the Egr2.NAB complex during peripheral nerve myelination

Mager, GM, Ward, RM, Srinivasan, R, Jang, SW, Wrabetz, L, Svaren, J

J. Biol. Chem. 2008
10611312 Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation

Zhu, J, Tseng, YH, Kantor, JD, Rhodes, CJ, Zetter, BR, Moyers, JS, Kahn, CR

Proc. Natl. Acad. Sci. U.S.A. 1999
19926875 Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart

Wang, G, Zhu, X, Xie, W, Han, P, Li, K, Sun, Z, Wang, Y, Chen, C, Song, R, Cao, C, Zhang, J, Wu, C, Liu, J, Cheng, H

Circ. Res. 2010
18056528 Rad GTPase deficiency leads to cardiac hypertrophy

Chang, L, Zhang, J, Tseng, YH, Xie, CQ, Ilany, J, BrĂ¼ning, JC, Sun, Z, Zhu, X, Cui, T, Youker, KA, Yang, Q, Day, SM, Kahn, CR, Chen, YE

Circulation 2007
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