NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates

Stable Identifier
R-HSA-9613023
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, cytosol
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NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates
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Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of nerve growth factor receptor tyrosine kinases (NTRKs). Adenosine (Ade-Rib), a neuromodulator acting through A2A receptors (ADORA2A), can transactivate NTRKs in the absence of neurotrophins (Jeanneteau & Chao 2006). The mechanism of this activation is not fully understood. After binding to Ade-Rib:ADORA2A, NTRK1 and NTRK2 autophosphorylate at 5 tyrosine residues.

Literature References
PubMed ID Title Journal Year
16805430 Promoting neurotrophic effects by GPCR ligands

Jeanneteau, F, Chao, MV

Novartis Found Symp 2006
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Ade-Rib:ADORA2A:NTRK1,2 [Golgi membrane]
Physical Entity
Ade-Rib:ADORA2A:NTRK1,2 [Golgi membrane]
Activity
protein tyrosine kinase activity (0004713)
Inferred From
Ntrk1,2,3 in Ade-Rib:Adora2a:Ntrk1,2,3 autophosphorylates (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Created
Jassal, B  (2018-07-06)