NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates

Stable Identifier
R-HSA-9613023
Type
Reaction
Species
Homo sapiens
Compartment
Golgi membrane, cytosol
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NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates
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Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of nerve growth factor receptor tyrosine kinases (NTRKs). Adenosine (Ade-Rib), a neuromodulator acting through A2A receptors (ADORA2A), can transactivate NTRKs in the absence of neurotrophins (Jeanneteau & Chao 2006). The mechanism of this activation is not fully understood. After binding to Ade-Rib:ADORA2A, NTRK1 and NTRK2 autophosphorylate at 5 tyrosine residues.

Literature References
PubMed ID Title Journal Year
16805430 Promoting neurotrophic effects by GPCR ligands

Jeanneteau, F, Chao, MV

Novartis Found Symp 2006
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Catalyst Activity

protein tyrosine kinase activity of Ade-Rib:ADORA2A:NTRK1,2 [Golgi membrane]

Physical Entity
Ade-Rib:ADORA2A:NTRK1,2 [Golgi membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Ntrk1,2,3 in Ade-Rib:Adora2a:Ntrk1,2,3 autophosphorylates (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Created
Jassal, B  (2018-07-06)
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