Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of nerve growth factor receptor tyrosine kinases (NTRKs). Adenosine (Ade-Rib), a neuromodulator acting through A2A receptors (ADORA2A), can transactivate NTRKs in the absence of neurotrophins (Jeanneteau & Chao 2006). The mechanism of this activation is not fully understood. After binding to Ade-Rib:ADORA2A, NTRK1 and NTRK2 autophosphorylate at 5 tyrosine residues.
Jeanneteau, F, Chao, MV
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