NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates

Stable Identifier
R-HSA-9612996
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, cytosol
ReviewStatus
5/5
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NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates
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Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of nerve growth factor receptor tyrosine kinases (NTRKs). Pituitary adenylate cyclase-activating polypeptide (ADCYAP1), a neuromodulator acting through type 1 PACAP receptors (ADCYAP1R1), can transactivate NTRKs (they autophosphorylate) in the absence of neurotrophins (Jeanneteau & Chao 2006). The mechanism of this activation is not fully understood.

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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 [Golgi membrane]

Physical Entity
ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 [Golgi membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Ntrk1,2,3 in Adcyap1:Adcyap1r1:Ntrk1,2,3 autophosphorylates (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Created
Jassal, B  (2018-07-05)
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