NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates

Stable Identifier
R-HSA-9612996
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of nerve growth factor receptor tyrosine kinases (NTRKs). Pituitary adenylate cyclase-activating polypeptide (ADCYAP1), a neuromodulator acting through type 1 PACAP receptors (ADCYAP1R1), can transactivate NTRKs (they autophosphorylate) in the absence of neurotrophins (Jeanneteau & Chao 2006). The mechanism of this activation is not fully understood.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 [Golgi membrane]
Physical Entity
Activity
Inferred From
Authored
Created