Autophagy

Stable Identifier
R-HSA-9612973
Type
Pathway
Species
Homo sapiens
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Autophagy is an intracellular degradation process that is triggered by cellular stresses. There are three primary types of autophagy - macroautophagy, chaperone-mediated autophagy (CMA) and late endosomal microautophagy. Despite being morphologically distinct, all three processes culminate in the delivery of cargo to the lysosome for degradation and recycling (Parzych KR et al, 2014). In macroautophagy a double membrane compartment sequesters the cargo and delivers it to the lysosome. Chaperones are used to deliver specific cargo proteins to the lysosome in CMA. In microautophagy invaginations of the endosomal membrane are used to capture cargo from the cytosol. Autophagy can target a wide range of entities ranging from bulk proteins and lipids to cell organelles and pathogens giving rise to several subclasses such as mitophagy, lipophagy, xenophagy, etc. (Shibutani ST 2014 et al).

Literature References
PubMed ID Title Journal Year
23725295 An overview of autophagy: morphology, mechanism, and regulation

Parzych, KR, Klionsky, DJ

Antioxid. Redox Signal. 2014
24296784 A current perspective of autophagosome biogenesis

Shibutani, ST, Yoshimori, T

Cell Res. 2014
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Event Information
Go Biological Process
Orthologous Events
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