NRG2-activated ERBB4 receptor binds to GABA receptors by directly interacting with the GABRA1 (GABA receptor alpha1) subunit. ERBB4 kinase activity is not necessary for interaction with GABRA1. ERBB4 binding reduces currents through the GABA receptor channel by promoting GABA receptor clearance from the postsynaptic membrane via clathrin-dependent endocytosis (Mitchell et al. 2013). The mechanism of endocytosis of GABRA1-containing GABA receptors via NRG2-bound ERBB4 is not known.
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