EGR1,2,3 bind the NAB2 promoter

Stable Identifier
R-HSA-9612483
Type
Reaction [binding]
Species
Homo sapiens
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NAB1 and 2 (NGFI-A binding protein) are transcriptional co-repressors that interact with EGR1, 2 and 3 and repress transcription of EGR target genes (Swirnoff et al, 1998; Svaren et al, 1996; Russo et al, 1995; Sevetson et al, 2000; Abdulkadir et al, 2001). NAB proteins may contribute to transcriptional repression through the recruitment of CHD4 (Srinivasan et al, 2006). Expression of NAB2 is regulated in part by the binding of EGR proteins to the cognate site in the NAB2 promoter (Kumbrink et al, 2005; Kumbrink et al, 2010).

Literature References
PubMed ID Title Journal Year
9418898 Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain

Swirnoff, AH, Apel, ED, Svaren, J, Sevetson, BR, Zimonjic, DB, Popescu, NC, Milbrandt, J

Mol. Cell. Biol. 1998
10734128 A novel activation function for NAB proteins in EGR-dependent transcription of the luteinizing hormone beta gene

Sevetson, BR, Svaren, J, Milbrandt, J

J. Biol. Chem. 2000
11567222 Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma

Abdulkadir, SA, Carbone, JM, Naughton, CK, Humphrey, PA, Catalona, WJ, Milbrandt, J

Hum. Pathol. 2001
8668170 NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli

Svaren, J, Sevetson, BR, Apel, ED, Zimonjic, DB, Popescu, NC, Milbrandt, J

Mol. Cell. Biol. 1996
16260776 Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop

Kumbrink, J, Gerlinger, M, Johnson, JP

J. Biol. Chem. 2005
7624335 Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription

Russo, MW, Sevetson, BR, Milbrandt, J

Proc. Natl. Acad. Sci. U.S.A. 1995
9774344 Novel mutants of NAB corepressors enhance activation by Egr transactivators

Svaren, J, Sevetson, BR, Golda, T, Stanton, JJ, Swirnoff, AH, Milbrandt, J

EMBO J. 1998
20506119 EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin

Kumbrink, J, Kirsch, KH, Johnson, JP

J. Cell. Biochem. 2010
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