MXD4 gene expression is stimulated by ERBB4s80

Stable Identifier
R-HSA-9612448
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm
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MXD4 gene expression is stimulated by ERBB4s80
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The intracellular fragment of the cyt1 isoform of ERBB4, ERBB4jmAcyt1s80, stimulates transcription of the MXD4 gene, encoding MAD-binding protein MXD4, which is thought to compete with MYC for MAD binding and thus interferes with MYC-mediated transcription (Wali et al. 2014).

Literature References
PubMed ID Title Journal Year
24829397 Convergent and divergent cellular responses by ErbB4 isoforms in mammary epithelial cells

Liu, Z, Gilmore-Hebert, M, Stern, DF, Wali, VB, Platt, JT, Haskins, JW

Mol. Cancer Res. 2014
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
ERBB4jmAcyt1s80:MXD4 gene [nucleoplasm] (Homo sapiens)
Active Unit
ERBB4jmAcyt1s80 dimer [nucleoplasm]
Authored
Stern, DF  (2019-02-21)
Orlic-Milacic, M  (2018-06-28)
Created
Orlic-Milacic, M  (2018-06-28)
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