MXD4 gene expression is stimulated by ERBB4s80

Stable Identifier
R-HSA-9612448
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
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MXD4 gene expression is stimulated by ERBB4s80
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The intracellular fragment of the cyt1 isoform of ERBB4, ERBB4jmAcyt1s80, stimulates transcription of the MXD4 gene, encoding MAD-binding protein MXD4, which is thought to compete with MYC for MAD binding and thus interferes with MYC-mediated transcription (Wali et al. 2014).

Literature References
PubMed ID Title Journal Year
24829397 Convergent and divergent cellular responses by ErbB4 isoforms in mammary epithelial cells

Wali, VB, Haskins, JW, Gilmore-Hebert, M, Platt, JT, Liu, Z, Stern, DF

Mol. Cancer Res. 2014
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Authored
Orlic-Milacic, M  (2018-06-28)
Stern, DF  (2019-02-21)
Created
Orlic-Milacic, M  (2018-06-28)