ERBB4s80 binds to SRC

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SRC tyrosine kinase, activated by EGFR signaling, binds to the cleaved intracellular fragment of ERBB4, ERBB4s80 (E4ICD), released in response to ERBB4 activation by NRG1. Tyrosine phosphorylation of ERBB4s80 is needed for SRC binding. It is not clear whether tyrosine phosphorylation sites are auto-phosphorylated or phosphorylated by SRC. SRC binding prevents translocation of ERBB4s80 to the nucleus (Ishibashi et al. 2012).

Literature References
PubMed ID Title Journal Year
23230144 Nuclear ErbB4 signaling through H3K9me3 is antagonized by EGFR-activated c-Src

Ishibashi, K, Fukumoto, Y, Hasegawa, H, Abe, K, Kubota, S, Aoyama, K, Kubota, S, Nakayama, Y, Yamaguchi, N

J. Cell. Sci. 2013
Participant Of
Orthologous Events
Cite Us!