Reactome | p-Y-GRIN2D [plasma membrane]

p-Y-GRIN2D [plasma membrane]

Stable Identifier

R-HSA-9612181

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-Y-GluN2D, p-Y-NR2D

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        Long-term potentiation (Homo sapiens)
        
        SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:p-Y-GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2A,C,D di-heteromers,GRIN1:p-Y-GRIN2 tri-heteromers [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2A:p-Y-GRIN2D tri-heterotetramer [plasma membrane] (Homo sapiens)
        
        p-Y-GRIN2D [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2B:p-Y-GRIN2D tri-heterotetramer [plasma membrane] (Homo sapiens)
        
        p-Y-GRIN2D [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2D di-heterotetramer [plasma membrane] (Homo sapiens)
        
        p-Y-GRIN2D [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15399 GRIN2D

Gene Names

GRIN2D, GluN2D, NMDAR2D

Chain

signal peptide:1-27, chain:28-1336

Reference Genes

BioGPS Gene:2906 GRIN2D

COSMIC (genes):GRIN2D GRIN2D

CTD Gene:2906 GRIN2D

dbSNP Gene:2906 GRIN2D

ENSEMBL:ENSG00000105464 GRIN2D

HGNC:4588 GRIN2D

KEGG:hsa:2906 GRIN2D

Monarch:2906 GRIN2D

NCBI Gene:2906 GRIN2D

OMIM:602717 GRIN2D

UCSC:O15399 GRIN2D

Reference Transcript

Other Identifiers

11728606_a_at

11728607_a_at

16863768

207036_PM_x_at

207036_x_at

229883_PM_at

229883_at

2906

31711_at

3837761

3837763

3837764

3837765

3837766

3837767

3837768

3837769

3837770

3837771

3837772

3837773

3837774

3837777

3837778

3837779

3837780

3837781

3837782

3837783

3837784

3837785

3837786

3837787

3837788

3837789

3837790

3837791

3837797

49839_at

8030022

A_23_P153549

A_33_P3402868

GE80822

GE858045

GO:0001964

GO:0004970

GO:0004972

GO:0005215

GO:0005216

GO:0005261

GO:0005515

GO:0005789

GO:0005886

GO:0006811

GO:0007215

GO:0007420

GO:0008344

GO:0015276

GO:0016020

GO:0016595

GO:0017146

GO:0019722

GO:0022824

GO:0022843

GO:0022849

GO:0023052

GO:0031090

GO:0034220

GO:0035235

GO:0035249

GO:0038023

GO:0045202

GO:0045211

GO:0048167

GO:0048168

GO:0048787

GO:0048856

GO:0050877

GO:0051930

GO:0051968

GO:0055085

GO:0060079

GO:0060089

GO:0060291

GO:0097553

GO:0098655

GO:0098686

GO:0098839

GO:0098976

GO:0098978

GO:0099505

GO:0099507

GO:1904062

GO:1904315

GO:1905232

GO:2000463

HMNXSV003034822

Hs.99389.0.A1_3p_at

ILMN_1740655

PH_hs_0027777

TC19000702.hg

g4504130_3p_at

Participates

as a component of

Other forms of this molecule

GRIN2D [endoplasmic reticulum membrane]

GRIN2D [plasma membrane]

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_011525174.1, NP_000827.2

Guide to Pharmacology - Targets

459

ENSEMBL

ENST00000263269, ENSP00000263269

OpenTargets

ENSG00000105464

ZINC - Substances

NMDE4_HUMAN

ZINC target

O15399

PRO

O15399

GlyGen

O15399

PDB

7YFO, 7YFM, 7YFL, 8E96, 7YFF, 7YFR

HPA

ENSG00000105464-GRIN2D

Pharos - Targets

O15399

Orphanet

GRIN2D

ZINC - Predictions - Purchasable

NMDE4_HUMAN

HMDB Protein

HMDBP01645