SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs

Stable Identifier
R-HSA-9612085
Type
Reaction [transition]
Species
Homo sapiens
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Non-receptor tyrosine kinase SRC phosphorylates GluN2 (GRIN2, NR2) subunits of the GluN2-containing NMDA receptors. This increases NMDA receptor open time and activity (Yu et al. 1997) and plays a role in long-term potentiation. SRC-mediated phosphorylation of NMDA receptors (NMDARs) is reduced in schizophrenia. Activation of ERBB4 signaling negatively regulates phosphorylation of NMDARs by SRC. ERBB4 signaling is hyperactivated in schizophrenia (Pitcher et al. 2011, Banerjee et al. 2015).

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Catalyst Activity
Title
protein tyrosine kinase activity of MyrG-p-Y419-SRC [plasma membrane]
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