ADRB2 bind ADR,NAd

Stable Identifier
Reaction [binding]
Homo sapiens
Beta-2 adrenoceptors bind catecholamines
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β-adrenergic receptors couple with G protein alpha-s subtype (Wenzel-Seifert K et al, 2002), increasing cAMP activity resulting in heart muscle contraction, smooth muscle relaxation and glycogenolysis. There are three β subtypes in humans; β1 found mainly in the heart and kidneys (Frielle et al. 1987), β2 found mainly in the lungs, vascular smooth muscle and skeletal muscle (Kobilka et al. 1987) and β3 found mainly in fat cells (Emorine et al. 1989). The catecholamines adrenaline (ADR) and noradrenaline (NaAd) are natural endogenous ligands that bind to β-adrenergic receptors and cause general physiological changes (increases in heart rate, blood pressure and glucose levels) that prepare the body for physical activity ('fight-or-flight response') (Tank & Lee Wong 2015).
Literature References
PubMed ID Title Journal Year
2570461 Molecular characterization of the human beta 3-adrenergic receptor

Strosberg, AD, Patey, G, Emorine, LJ, Marullo, S, Delavier-Klutchko, C, Tate, K, Briend-Sutren, MM

Science 1989
12106601 Similarities and differences in the coupling of human beta1- and beta2-adrenoceptors to Gs(alpha) splice variants

Liu, HY, Seifert, R, Wenzel-Seifert, K

Biochem Pharmacol 2002
2825170 Cloning of the cDNA for the human beta 1-adrenergic receptor

Daniel, KW, Caron, MG, Lefkowitz, RJ, Frielle, T, Collins, S, Kobilka, BK

Proc Natl Acad Sci U S A 1987
3025863 cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor

Bolanowski, MA, Caron, MG, Lefkowitz, RJ, Frielle, T, Yang-Feng, TL, Dixon, RA, Kobilka, BK, Francke, U, Sigal, IS, Dohlman, HG

Proc Natl Acad Sci U S A 1987
This event is regulated
Orthologous Events
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