Reactome | CAMK2G [cytosol]

CAMK2G [cytosol]

Stable Identifier

R-HSA-9611358

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ca/calmodulin dependent proetin kinase II gamma subunit

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Assembly and cell surface presentation of NMDA receptors (Homo sapiens)
        
        CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
      - Negative regulation of NMDA receptor-mediated neuronal transmission (Homo sapiens)
        
        CALM1:4xCa2+ binds GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors and displaces ACTN2 (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:LRRC7:CaMKII dodecamer [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        PPM1F dephosphorylates p-T286-CaMKII (Homo sapiens)
        
        CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Homo sapiens)
        
        Ras activation upon Ca2+ influx through NMDA receptor (Homo sapiens)
        
        Activation of RasGRF (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        NMDA-activated RASGRF1 activates RAS (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        Long-term potentiation (Homo sapiens)
        
        CaMKII autophosphorylates (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        CaMKII binds activated NMDA receptor (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        CaMKII binds activated calmodulin (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        CaMKII phosphorylates AMPA receptor (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:p-Y-GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:p-Y-GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
      - Unblocking of NMDA receptors, glutamate binding and activation (Homo sapiens)
        
        Ca2+ influx into the post-synaptic cell (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        Glycine and glutamate ligands bind GRIN1:GRIN2 NMDA receptor (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        Mg2+ binds GRIN1:GRIN2 NMDA receptors (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins:Mg2+ [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CaMKII autophosphorylates (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        CaMKII binds activated calmodulin (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
        
        RAS GEFs [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Homo sapiens)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CaMKII autophosphorylates (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        CaMKII binds activated calmodulin (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)
        
        CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        CaMKII dodecamer [cytosol] (Homo sapiens)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)
        
        CAMK2G [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13555 CAMK2G

Gene Names

CAMK2G, CAMK, CAMK-II, CAMKG

Chain

chain:1-558

Reference Genes

BioGPS Gene:818 CAMK2G

COSMIC (genes):CAMK2G CAMK2G

CTD Gene:818 CAMK2G

dbSNP Gene:818 CAMK2G

ENSEMBL:ENSG00000148660 CAMK2G

HGNC:1463 CAMK2G

KEGG:hsa:818 CAMK2G

Monarch:818 CAMK2G

NCBI Gene:818 CAMK2G

OMIM:602123 CAMK2G

UCSC:Q13555 CAMK2G

Reference Transcript

Participates

as a candidate of

CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Homo sapiens)

Other forms of this molecule

p-T287-CAMK2G [cytosol]

p-T287-CAMK2G [nucleoplasm]

p-T287-CAMK2G [endocytic vesicle membrane]

p-T287-CAMK2G [plasma membrane]

p-T287-CAMK2G [endoplasmic reticulum membrane]

Inferred To

CaMKII [cytosol] (Drosophila melanogaster)

camk2g [cytosol] (Xenopus tropicalis)

unc-43 [cytosol] (Caenorhabditis elegans)

CAMK2G [cytosol] (Bos taurus)

CAMK2G [cytosol] (Canis familiaris)

CAMK2G [cytosol] (Gallus gallus)

CAMK2G [cytosol] (Sus scrofa)

Camk2g [cytosol] (Mus musculus)

Camk2g [cytosol] (Rattus norvegicus)

Cross References

RefSeq

XP_005270260.1, NP_001191421.1, NP_001354460.1, NP_751909.1, NP_001213.2, NP_001307827.1, NP_751913.1

ZINC - World Drugs

KCC2G_HUMAN

Guide to Pharmacology - Targets

1557

OpenTargets

ENSG00000148660

ENSEMBL

ENSP00000277853, ENST00000305762, ENSP00000315599, ENSG00000148660, ENSP00000307082, ENST00000680035, ENSP00000505103, ENST00000351293, ENST00000322635

ZINC - FDA approved

KCC2G_HUMAN

ZINC - Substances

KCC2G_HUMAN

ZINC - Biogenic

KCC2G_HUMAN

ZINC target

Q13555

PRO

Q13555

GlyGen

Q13555

PDB

2V7O, 2UX0

ZINC - Investigational

KCC2G_HUMAN

HPA

ENSG00000148660-CAMK2G

GeneCards

CAMK2G

Pharos - Targets

Q13555

ZINC - Predictions - Purchasable

KCC2G_HUMAN

HMDB Protein

HMDBP09421

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.527	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.524	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	2

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