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Endocytic Uptake of HCMV Virion
Stable Identifier
R-HSA-9611147
Type
Reaction [dissociation]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
plasma membrane
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Early Events (Homo sapiens)
Endocytic Uptake of HCMV Virion (Homo sapiens)
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Once the pentameric viral protein complex, gH:gL:p128:p130:p131A, facilitates attchment of the Human Cytomegalovirus (HCMV) endocytic uptake allows the virion to enter epithelial and endothelial cells. The virion is released from the endocytic vesicle by low-pH-dependent fusion of the virion coat with endosomes membrane.
Literature References
PubMed ID
Title
Journal
Year
Fields Virology
Knipe, DM
,
Howley, PM
2013
Participants
Input
Enveloped HCMV Virion Bound to Entry Mediator [extracellular region]
(Homo sapiens)
Output
gB Homodimer [endosome membrane]
(Human cytomegalovirus)
gH:gL:gO (gCIII) [endosome membrane]
(Human cytomegalovirus)
gH:gL:UL128:UL130:UL131A [endosome membrane]
(Human cytomegalovirus)
gM:gN [endosome membrane]
(Human cytomegalovirus)
HCMV Host Cell Receptors [endosome membrane]
(Homo sapiens)
HCMV Tegumented Virion [viral tegument]
(Human cytomegalovirus)
HSPG [plasma membrane]
Participates
as an event of
HCMV Early Events (Homo sapiens)
Event Information
Go Biological Process
symbiont entry into host cell (0046718)
Disease
Name
Identifier
Synonyms
viral infectious disease
DOID:934
Viral disease, virus infection, virus infection
Authored
Gillespie, ME (2018-06-14)
Reviewed
Streblow, DN (2019-10-18)
Caposio, P (2019-10-18)
Created
Gillespie, ME (2018-06-15)
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