HCMV Binds Host Cell Receptor - Endocytic Pathway

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Human cytomegalovirus
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Viral attachment and penetration of Human Cytomegalovirus (HCMV) occurs either via direct HCMV fusion with the cell membrane or via endocytosis. The endocytic mechanism occurs with cell types including endothelial and epithelial cells, where the pentameric viral protein complex, gH:gL:p128:p130:p131A, facilitates entry.

Literature References
PubMed ID Title Journal Year
  Fields Virology

Knipe, DM, Howley, PM

18203656 Entry route of HCMV into endothelial cells

Sinzger, C

J. Clin. Virol. 2008
22174689 The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells

Gabaev, I, Steinbr├╝ck, L, Pokoyski, C, Pich, A, Stanton, RJ, Schwinzer, R, Schulz, TF, Jacobs, R, Messerle, M, Kay-Fedorov, PC

PLoS Pathog. 2011
21690215 Heparan sulfate proteoglycans

Sarrazin, S, Lamanna, WC, Esko, JD

Cold Spring Harb Perspect Biol 2011
Participant Of
Name Identifier Synonyms
viral infectious disease 934 arbovirus infectious disease, Viral disease, Viral infection NOS, Viral infection, unspecified (disorder), Viral infection NOS, Viral disease (disorder), Viral disease, Viral infection NOS (disorder), Viral Infection, virus infection, virus infection, Viral: [infection NOS] or [illness]