HCMV Binds Host Cell Receptor - Endocytic Pathway

Stable Identifier
R-HSA-9610867
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
extracellular region
ReviewStatus
5/5
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HCMV Binds Host Cell Receptor - Endocytic Pathway
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Viral attachment and penetration of Human Cytomegalovirus (HCMV) occurs either via direct HCMV fusion with the cell membrane or via endocytosis. The endocytic mechanism occurs with cell types including endothelial and epithelial cells, where the pentameric viral protein complex, gH:gL:p128:p130:p131A, facilitates entry.
Literature References
PubMed ID Title Journal Year
18203656 Entry route of HCMV into endothelial cells

Sinzger, C

J. Clin. Virol. 2008
  Fields Virology

Knipe, DM, Howley, PM

  2013
22174689 The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells

Gabaev, I, Steinbrück, L, Pokoyski, C, Pich, A, Stanton, RJ, Schwinzer, R, Schulz, TF, Jacobs, R, Messerle, M, Kay-Fedorov, PC

PLoS Pathog. 2011
21690215 Heparan sulfate proteoglycans

Sarrazin, S, Lamanna, WC, Esko, JD

Cold Spring Harb Perspect Biol 2011
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
viral infectious disease DOID:934 Viral disease, virus infection, virus infection
Cross References
Mondo
Authored
Gillespie, ME  (2018-05-30)
Reviewed
Caposio, P  (2019-10-18)
Streblow, DN  (2019-10-18)
Created
Gillespie, ME  (2018-06-13)
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