GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors bind to postsynaptic density proteins

Stable Identifier
R-HSA-9610653
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors bind to postsynaptic density proteins
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All GluN2 (GRIN2) family subunits, GluN2A (GRIN2A), GluN2B (GRIN2B), GluN2C (GRIN2C) and GluN2D (GRIN2D), can bind to any of the PSD-95 protein family members DLG1 (SAP-97), DLG2 (PSD-93), DLG3 (SAP-102) and DLG4 (PSD-95). Binding to different PSD-95 family members does not affect transport of GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors to the plasma membrane, but does affect their positioning and retention at the plasma membrane postsynaptic density, as well as their excitability (Cui et al. 2007, Cousins et al. 2008, Bard et al. 2010). DLG4, the most prominent postsynaptic density protein, can also interact directly with GluN1 isoforms that possess the PDZ-binding domain in their C-terminus (Kornau et al. 1995).
Literature References
PubMed ID Title Journal Year
17855605 PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors

Garman, D, Cui, H, Tymianski, M, Phan, T, Sun, HS, Lu, PS, Belmares, MP, Salter, MW, Tasker, RA, Hayashi, A, Wang, YT, Cobey, C, Schweizer, J, Rabinowitz, J

J. Neurosci. 2007
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Inferred From
GluN1 (Grin1) binds to Dlg4 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2019-01-05)
Reviewed
Traynelis, SF  (2019-02-11)
Camp, C  (2019-02-11)
Bhattacharya, S  (2019-02-11)
Created
Orlic-Milacic, M  (2018-06-11)
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