Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN3A (GRIN3A)

Stable Identifier
R-HSA-9610270
Type
Reaction [binding]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN3A (GRIN3A)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

GluN1 (GRIN1) binds to GluN2A (GRIN2A) and GluN3A (GRIN3A) to form a tri-heteromeric GluN1:GluN2A:GluN3A (GRIN1:GRIN2A:GRIN3A) NMDA receptor (Perez-Otano et al. 2001, Nilsson et al. 2007, Tong et al. 2008).

Literature References
PubMed ID Title Journal Year
17997397 Analysis of NR3A receptor subunits in human native NMDA receptors

Samuelsson, EB, Nilsson, A, Muly, EC, Sundström, E, Eriksson, M, Benedikz, E, Bogdanovic, N, Akesson, E

Brain Res. 2007
Participants
Input
Output
Participates
as an event of
Inferred From
Formation of tri-heterotetramers of GluN1 (Grin1), GluN2A (Grin2a) and GluN3A (Grin3a) (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2019-01-05)
Reviewed
Traynelis, SF  (2019-02-11)
Camp, C  (2019-02-11)
Bhattacharya, S  (2019-02-11)
Created
Orlic-Milacic, M  (2018-06-06)
Cite Us!