BRAF autophosphorylates downstream of RAP1 and NGF

Stable Identifier
R-HSA-9610163
Type
Reaction
Species
Homo sapiens
Compartment
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After recruitment by RAP1 to the endosome, BRAF is activated, likely by autophosphorylation on the activation loop serines at 599 and 602 (Kao et al, 2001; reviewed in Matallanas, 2011).

Literature References
PubMed ID Title Journal Year
11278445 Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells

Kao, S, Kolch, W, Landreth, GE, Jaiswal, RK

J Biol Chem 2001
21779496 Raf family kinases: old dogs have learned new tricks

Romano, D, Matallanas, D, Rauch, J, Zebisch, A, Birtwistle, M, Kolch, W, von Kriegsheim, A

Genes Cancer 2011
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of RAP1:GTP:B-Raf complex [endosome membrane]

Orthologous Events
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