After recruitment by RAP1 to the endosome, BRAF is activated, likely by autophosphorylation on the activation loop serines at 599 and 602 (Kao et al, 2001; reviewed in Matallanas, 2011).
Kao, S, Kolch, W, Landreth, GE, Jaiswal, RK
Romano, D, Matallanas, D, Rauch, J, Zebisch, A, Birtwistle, M, Kolch, W, von Kriegsheim, A
protein serine/threonine kinase activity of RAP1:GTP:B-Raf complex [endosome membrane]
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