After recruitment by RAP1 to the endosome, BRAF is activated, likely by autophosphorylation on the activation loop serines at 599 and 602 (Kao et al, 2001; reviewed in Matallanas, 2011).
Matallanas, D, Birtwistle, M, Romano, D, Zebisch, A, Rauch, J, von Kriegsheim, A, Kolch, W
Kao, S, Jaiswal, RK, Kolch, W, Landreth, GE
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