Reactome | BRAF autophosphorylates downstream of RAP1 and NGF

BRAF autophosphorylates downstream of RAP1 and NGF

Stable Identifier

R-HSA-9610163

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endosome membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Signalling to ERKs (Homo sapiens)
        
        Prolonged ERK activation events (Homo sapiens)
        
        Frs2-mediated activation (Homo sapiens)
        
        BRAF autophosphorylates downstream of RAP1 and NGF (Homo sapiens)

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BRAF autophosphorylates downstream of RAP1 and NGF

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After recruitment by RAP1 to the endosome, BRAF is activated, likely by autophosphorylation on the activation loop serines at 599 and 602 (Kao et al, 2001; reviewed in Matallanas, 2011).

Literature References

PubMed ID	Title	Journal	Year
11278445	Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells Kao, S, Kolch, W, Landreth, GE, Jaiswal, RK	J Biol Chem	2001
21779496	Raf family kinases: old dogs have learned new tricks Romano, D, Matallanas, D, Rauch, J, Zebisch, A, Birtwistle, M, Kolch, W, von Kriegsheim, A	Genes Cancer	2011