BRAF autophosphorylates downstream of RAP1 and NGF

Stable Identifier
R-HSA-9610163
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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After recruitment by RAP1 to the endosome, BRAF is activated, likely by autophosphorylation on the activation loop serines at 599 and 602 (Kao et al, 2001; reviewed in Matallanas, 2011).

Literature References
PubMed ID Title Journal Year
21779496 Raf family kinases: old dogs have learned new tricks

Matallanas, D, Birtwistle, M, Romano, D, Zebisch, A, Rauch, J, von Kriegsheim, A, Kolch, W

Genes Cancer 2011
11278445 Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells

Kao, S, Jaiswal, RK, Kolch, W, Landreth, GE

J Biol Chem 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of RAP1:GTP:B-Raf complex [endosome membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created