Reactome | Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A)

Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A)

Stable Identifier

R-HSA-9609742

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A)

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GluN2A (GRIN2A) forms a di-heterotetramer with GluN1 (GRIN1). Based on the crystal structure of the rat GluN1:GluN2A (Grin1:Grin2a) NMDA receptor (Furukawa et al. 2005) and the Cryo-EM structure of the human GluN1:GluN2A (GRIN1:GRIN2A) NMDA receptor (Zhang et al. 2018), the tetramer includes 2 molecules of GluN1 and two molecules of GluN2A. GluN2A expression starts postnatally and GluN2A is highly expressed in adult brain (Monyer et al. 1992, Sheng et al. 1994).

Literature References

PubMed ID	Title	Journal	Year
30590034	Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors Zhang, JB, Chang, S, Xu, P, Miao, M, Wu, H, Zhang, Y, Zhang, T, Wang, H, Zhang, J, Xie, C, Song, N, Luo, C, Zhang, X, Zhu, S	Cell Rep	2018