Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A)

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

GluN2A (GRIN2A) forms a di-heterotetramer with GluN1 (GRIN1). Based on the crystal structure of the rat GluN1:GluN2A (Grin1:Grin2a) NMDA receptor (Furukawa et al. 2005) and the Cryo-EM structure of the human GluN1:GluN2A (GRIN1:GRIN2A) NMDA receptor (Zhang et al. 2018), the tetramer includes 2 molecules of GluN1 and two molecules of GluN2A. GluN2A expression starts postnatally and GluN2A is highly expressed in adult brain (Monyer et al. 1992, Sheng et al. 1994).

Literature References
PubMed ID Title Journal Year
30590034 Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors

Zhang, JB, Chang, S, Xu, P, Miao, M, Wu, H, Zhang, Y, Zhang, T, Wang, H, Zhang, J, Xie, C, Song, N, Luo, C, Zhang, X, Zhu, S

Cell Rep 2018
Participant Of
Orthologous Events
Cite Us!