HCMV Binds to the Host Cell via heparan sulfate proteoglycans (HSPG)

Stable Identifier
R-HSA-9609689
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Human cytomegalovirus
Compartment
extracellular region
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HCMV Binds to the Host Cell via heparan sulfate proteoglycans (HSPG)
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Viral attachment and penetration of Human Cytomegalovirus (HCMV) occurs either via direct HCMV fusion with the cell membrane or via endocytosis. The endocytic mechanism occurs with cell types including endothelial and epithelial cells, where the pentameric viral protein complex, gH:gL:p128:p130:p131A, facilitates entry.

Literature References
PubMed ID Title Journal Year
  Fields Virology

Knipe, DM, Howley, PM

  2013
16140760 Deletion of gpUL132, a structural component of human cytomegalovirus, results in impaired virus replication in fibroblasts

Lu, S, Coley, S, Mach, M, Kropff, B, Spaderna, S, Britt, W, Shen, S, Ködel, Y

J. Virol. 2005
21690215 Heparan sulfate proteoglycans

Sarrazin, S, Esko, JD, Lamanna, WC

Cold Spring Harb Perspect Biol 2011
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
viral infectious disease DOID:934 Viral disease, virus infection, virus infection
Authored
Gillespie, ME  (2018-05-30)
Reviewed
Streblow, DN  (2019-10-18)
Caposio, P  (2019-10-18)
Created
Gillespie, ME  (2018-05-30)
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