Reactome | WRB [endoplasmic reticulum membrane]

WRB [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9609521

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Tail-anchored protein insertion receptor WRB, WRB_HUMAN

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External Reference Information

External Reference

UniProt:O00258 GET1

Gene Names

GET1, CHD5, WRB

Chain

chain:1-174

Reference Genes

BioGPS Gene:7485 GET1

COSMIC (genes):CHD5 CHD5

COSMIC (genes):WRB GET1

CTD Gene:7485 GET1

dbSNP Gene:7485 GET1

ENSEMBL:ENSG00000182093 WRB

HGNC:12790 GET1

KEGG:hsa:7485 GET1

Monarch:7485 GET1

NCBI Gene:7485 GET1

OMIM:602915 GET1

UCSC:O00258 GET1

Reference Transcript

Other Identifiers

11739305_a_at

11748877_s_at

11748878_x_at

11760995_a_at

11761399_at

11762780_a_at

11762781_at

16922824

202749_at

32777_at

3921392

3921393

3921394

3921395

3921397

3921398

3921399

3921400

3921401

3921402

3921403

3921404

3921405

3921406

3921407

3921408

3921409

3921411

3921412

3921413

3921414

3921415

3921416

3921422

3921424

3921425

3921426

3921428

3921429

3957550

72571_at

72573_g_at

72575_at

7485

80437_at

8068612

A_14_P117203

A_14_P126076

A_23_P80122

GE62709

GO:0005515

GO:0005634

GO:0005783

GO:0005789

GO:0016020

GO:0043226

GO:0043495

GO:0043529

GO:0045048

GO:0050821

GO:0060090

GO:0071816

GO:0090150

HMNXSV003002679

HMNXSV003050506

ILMN_1695092

ILMN_2085922

PH_hs_0011683

PH_hs_0032127

Y12478_at

g4759325_3p_at

Participates

as a component of

WRB:CAMLG [endoplasmic reticulum membrane] (Homo sapiens)

Cross References

ENSEMBL

ENST00000649170, ENSP00000496813, ENSG00000182093, ENSP00000497103, ENSP00000381737, ENSP00000370084, ENST00000650376, ENST00000398753, ENST00000380708

OpenTargets

ENSG00000182093

GeneCards

GET1

HPA

ENSG00000182093-GET1

PRO

O00258

Pharos - Targets

O00258

PDB

8CQZ, 8CR2, 6SO5, 8CR1

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02652 APOA2	6	APOA2(24-100) [cytosol] (R-HSA-2395772) APOA2(24-100) [early endosome] (R-HSA-2569092) APOA2(24-100) [endoplasmic reticulum lumen] (R-HSA-174689) APOA2(24-100) [extracellular region] (R-HSA-174775) p-APOA2 [endoplasmic reticulum lumen] (R-HSA-8957014) APOA2 [endoplasmic reticulum lumen] (R-HSA-8956780)	0.556	3
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.556	3
UniProt:Q5QGT7 RTP2	2	RTP2 [endoplasmic reticulum membrane] (R-HSA-9752982) RTP2 [plasma membrane] (R-HSA-8939446)	0.556	3
UniProt:Q8WTS1 ABHD5	2	ABHD5 [lipid droplet] (R-HSA-163485) ABHD5 [cytosol] (R-HSA-163531)	0.556	3
UniProt:P21964 COMT	2	COMT [cytosol] (R-HSA-175974) COMT [plasma membrane] (R-HSA-379386)	0.556	3