NR1H2,3 binds the PLIN1 gene

Stable Identifier
R-HSA-9608039
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
LXR binds the PLIN1 gene
ReviewStatus
5/5
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NR1H2,3 binds the PLIN1 gene
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The Reactome event shows liver X receptor (LXR or NR1H2 or NR1H3)-mediated regulation of the perilipin 1 (PLIN1) gene by naturally occurring NR1H2,3 agonists, oxysterols. This event is based on the data reported for the synthetic agonist GW3965 (Stenson BM et al. 2011). Upon activation by GW3965, NR1H2 (or NR1H3) was found to bind to the proximal regions of the PLIN1 promoter to downregulate PLIN1 expression in differentiated human and murine adipocytes. By selective knockdown of either NR1H2 or NR1H3 using siRNA in human adipocytes, NR1H3 (LXRα) was shown to be the major isoform mediating the lipolysis-related effects of NR1H2,3 (Stenson BM et al. 2011).

Literature References
PubMed ID Title Journal Year
21030586 Liver X receptor (LXR) regulates human adipocyte lipolysis

Arner, P, Langin, D, Blomqvist, L, Wang, V, Mairal, A, Laurencikiene, J, Stenson, BM, Jocken, JW, Dahlman, I, Pettersson, AM, Rydén, M, Venteclef, N, Aström, G, Clément, K

J. Biol. Chem. 2011
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Authored
Shamovsky, V  (2018-01-19)
Reviewed
D'Eustachio, P  (2018-12-29)
Repa, JJ  (2019-08-09)
Cummins, CL  (2019-08-09)
Created
Shamovsky, V  (2018-05-09)
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