Active FLT3:GRB2 binds SOS1

Stable Identifier
R-HSA-9607301
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Active FLT3:GRB2 binds SOS1
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Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a member of the class III tyrosine kinase receptor family. Ligand binding induces conformational changes in the FLT3 receptor, which facilitates its dimerization and autophosphorylation. Once fully active, FLT3 receptors can associate with growth factor receptor-bound protein 2 (GRB2), which then recruits Son of sevenless homolog 1 (SOS1). Consequently, this triggers the activation of the ERK signaling cascade (Li et al. 1993).
Literature References
PubMed ID Title Journal Year
8479541 Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling.

Yajnik, V, Skolnik, E, Batzer, A, Daly, R, Li, N, Schlessinger, J, Margolis, B

Nature 1993
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Orthologous Events
Active FLT3:GRB2 binds SOS1 (Bos taurus)
Active FLT3:GRB2 binds SOS1 (Canis familiaris)
Active FLT3:GRB2 binds SOS1 (Mus musculus)
Active FLT3:GRB2 binds SOS1 (Sus scrofa)
Authored
Varusai, TM  (2019-01-14)
Reviewed
Traer, E  (2019-05-03)
Joshi, S  (2019-05-21)
Created
Varusai, TM  (2018-05-02)
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