BTK autophosphorylates

Stable Identifier
R-HSA-9606159
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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BTK autophosphorylates
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After phosphorylation on tyrosine-551 by LYN or SYK, BTK autophosphorylates tyrosine-223 (Wahl et al. 1997, Nore et al. 2003, and inferred from mouse homologs). Maximum autophosphorylation occurs 5 minutes after activation of the B cell receptor and returns to low phosphorylation after 30 minutes (Nisitani et al. 1999).

Literature References
PubMed ID Title Journal Year
12573241 Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases

Nore, BF, Mattsson, PT, Antonsson, P, Bäckesjö, CM, Westlund, A, Lennartsson, J, Hansson, H, Löw, P, Rönnstrand, L, Smith, CI

Biochim. Biophys. Acta 2003
10051622 In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies

Nisitani, S, Kato, RM, Rawlings, DJ, Witte, ON, Wahl, MI

Proc. Natl. Acad. Sci. U.S.A. 1999
9326643 Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors

Wahl, MI, Fluckiger, AC, Kato, RM, Park, H, Witte, ON, Rawlings, DJ

Proc. Natl. Acad. Sci. U.S.A. 1997
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane]
Physical Entity
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane]
Activity
protein tyrosine kinase activity (0004713)
Inferred From
Btk autophosphorylates (Mus musculus)
Authored
May, B  (2018-04-14)
Reviewed
Wienands, J  (2018-07-18)
Created
May, B  (2018-04-19)