BTK autophosphorylates

Stable Identifier
Homo sapiens
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After phosphorylation on tyrosine-551 by LYN or SYK, BTK autophosphorylates tyrosine-223 (Wahl et al. 1997, Nore et al. 2003, and inferred from mouse homologs). Maximum autophosphorylation occurs 5 minutes after activation of the B cell receptor and returns to low phosphorylation after 30 minutes (Nisitani et al. 1999).

Literature References
PubMed ID Title Journal Year
10051622 In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies

Witte, ON, Kato, RM, Wahl, MI, Rawlings, DJ, Nisitani, S

Proc. Natl. Acad. Sci. U.S.A. 1999
12573241 Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases

Bäckesjö, CM, Nore, BF, Smith, CI, Mattsson, PT, Hansson, H, Westlund, A, Antonsson, P, Rönnstrand, L, Lennartsson, J, Löw, P

Biochim. Biophys. Acta 2003
9326643 Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors

Park, H, Witte, ON, Kato, RM, Fluckiger, AC, Wahl, MI, Rawlings, DJ

Proc. Natl. Acad. Sci. U.S.A. 1997
Catalyst Activity

protein tyrosine kinase activity of Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane]

Inferred From
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