Reactome | BTK autophosphorylates

BTK autophosphorylates

Stable Identifier

R-HSA-9606159

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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After phosphorylation on tyrosine-551 by LYN or SYK, BTK autophosphorylates tyrosine-223 (Wahl et al. 1997, Nore et al. 2003, and inferred from mouse homologs). Maximum autophosphorylation occurs 5 minutes after activation of the B cell receptor and returns to low phosphorylation after 30 minutes (Nisitani et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10051622	In situ detection of activated Bruton's tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies Witte, ON, Kato, RM, Wahl, MI, Rawlings, DJ, Nisitani, S	Proc. Natl. Acad. Sci. U.S.A.	1999
12573241	Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases Bäckesjö, CM, Nore, BF, Smith, CI, Mattsson, PT, Hansson, H, Westlund, A, Antonsson, P, Rönnstrand, L, Lennartsson, J, Löw, P	Biochim. Biophys. Acta	2003
9326643	Phosphorylation of two regulatory tyrosine residues in the activation of Bruton's tyrosine kinase via alternative receptors Park, H, Witte, ON, Kato, RM, Fluckiger, AC, Wahl, MI, Rawlings, DJ	Proc. Natl. Acad. Sci. U.S.A.	1997