Reactome | B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda

B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda

Stable Identifier

R-HSA-9605700

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

ReviewStatus

5/5

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B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda

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Beta-1,4 N-acetylgalactosaminyltransferase 2 (B4GALNT2), resident on the Golgi membrane, mediates the formation of the Sda antigen through the addition of an N-acetylgalactosamine (GalNAc) residue via a β1,4-linkage to the sub-terminal galactose residue substituted with an α2,3-linked sialic acid residue (Montiel et al. 2003, Lo Presti et al. 2003). The Sda antigen is a carbohydrate determinant expressed on erythrocytes and secretions of the vast majority of Caucasians and ethnic groups and its expression has an impact on the physiology and the pathology of several biological systems (Dall'Olio et al. 2014). In normal colon, B4GALNT2 levels are high and control the biosynthesis of Sda while at the same time inhibiting the formation of sialyl-Lewis X antigen (sLeX), involved in metastasis (Groux-Degroote et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
14688233	Molecular cloning of the human beta1,4 N-acetylgalactosaminyltransferase responsible for the biosynthesis of the Sd(a) histo-blood group antigen: the sequence predicts a very long cytoplasmic domain Cabuy, E, Dall'Olio, F, Chiricolo, M, Lo Presti, L	J. Biochem.	2003
12678917	Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain Delannoy, P, Krzewinski-Recchi, MA, Montiel, MD, Harduin-Lepers, A	Biochem. J.	2003
24953560	B4GALNT2 gene expression controls the biosynthesis of Sda and sialyl Lewis X antigens in healthy and cancer human gastrointestinal tract Dall'Olio, F, Chiricolo, M, Delannoy, P, Wavelet, C, Malagolini, N, Krzewinski-Recchi, MA, Mihalache, A, Trinchera, M, Groux-Degroote, S, Harduin-Lepers, A, Portier, L, Mortuaire, M	Int. J. Biochem. Cell Biol.	2014