B4GALNT2 transfers GalNAc to Type 2 MSGG to form Sda

Stable Identifier
R-HSA-9605700
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Beta-1,4 N-acetylgalactosaminyltransferase 2 (B4GALNT2), resident on the Golgi membrane, mediates the formation of the Sda antigen through the addition of an N-acetylgalactosamine (GalNAc) residue via a β1,4-linkage to the sub-terminal galactose residue substituted with an α2,3-linked sialic acid residue (Montiel et al. 2003, Lo Presti et al. 2003). The Sda antigen is a carbohydrate determinant expressed on erythrocytes and secretions of the vast majority of Caucasians and ethnic groups and its expression has an impact on the physiology and the pathology of several biological systems (Dall'Olio et al. 2014). In normal colon, B4GALNT2 levels are high and control the biosynthesis of Sda while at the same time inhibiting the formation of sialyl-Lewis X antigen (sLeX), involved in metastasis (Groux-Degroote et al. 2014).

Literature References
PubMed ID Title Journal Year
12678917 Molecular cloning, gene organization and expression of the human UDP-GalNAc:Neu5Acalpha2-3Galbeta-R beta1,4-N-acetylgalactosaminyltransferase responsible for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain

Montiel, MD, Krzewinski-Recchi, MA, Delannoy, P, Harduin-Lepers, A

Biochem. J. 2003
14688233 Molecular cloning of the human beta1,4 N-acetylgalactosaminyltransferase responsible for the biosynthesis of the Sd(a) histo-blood group antigen: the sequence predicts a very long cytoplasmic domain

Lo Presti, L, Cabuy, E, Chiricolo, M, Dall'Olio, F

J. Biochem. 2003
24953560 B4GALNT2 gene expression controls the biosynthesis of Sda and sialyl Lewis X antigens in healthy and cancer human gastrointestinal tract

Groux-Degroote, S, Wavelet, C, Krzewinski-Recchi, MA, Portier, L, Mortuaire, M, Mihalache, A, Trinchera, M, Delannoy, P, Malagolini, N, Chiricolo, M, Dall'Olio, F, Harduin-Lepers, A

Int. J. Biochem. Cell Biol. 2014
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
acetylgalactosaminyltransferase activity of B4GALNT2 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created