FUT3 transfers Fuc to Type 1 DSGG to form dsLeA

Stable Identifier
R-HSA-9605644
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The FUT3 gene (originally named the Le gene) expresses galactoside 3(4)-L-fucosyltransferase present on the Golgi membrane. FUT3 catalyses the α1,4 and α1,3 addition of fucose to Type 1 and Type 2 oligosaccharide chains respectively, thereby playing a role in Lewis blood group determination (Kukowska-Latallo et al. 1990). Here, the addition of fucose to the subterminal N-acetylglucosaminyl (GlcNAc) residue of Type 1 disialylgalactosylgloboside (Type 1 DSGG) in an α1,4 linkage forms the disialyl-Lewis A antigen (dsLeA).

Literature References
PubMed ID Title Journal Year
1977660 A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase

Kukowska-Latallo, JF, Larsen, RD, Nair, RP, Lowe, JB

Genes Dev. 1990
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
alpha-(1->3)-fucosyltransferase activity of FUT3 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created