FUT3 transfers Fuc to Type 1 MSGG to form sLeA

Stable Identifier
Reaction [transition]
Homo sapiens
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The FUT3 gene (originally named the Le gene) expresses galactoside 3(4)-L-fucosyltransferase present on the Golgi membrane. FUT3 catalyses the α1,4 and α1,3 addition of fucose to Type 1 and Type 2 oligosaccharide chains respectively, thereby playing a role in Lewis blood group determination (Kukowska-Latallo et al. 1990). Here, the addition of fucose to the subterminal N-acetylglucosaminyl (GlcNAc) residue of Type 1 monosialylgalactosylgloboside (Type 1 MSGG) in an α1,4 linkage forms the sialyl Lewis A antigen (sLeA), also known as the CA19-9 antigen, the most common tumour marker used primarily in the management of pancreatic and gastrointestinal cancers worldwide (Magnani 2004). If CA19-9 is initially elevated in pancreatic cancer, it may be requested several times during cancer treatment to monitor response and, on a regular basis following treatment, to help detect recurrence of the cancer.
Literature References
PubMed ID Title Journal Year
1977660 A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase

Larsen, RD, Lowe, JB, Kukowska-Latallo, JF, Nair, RP

Genes Dev. 1990
15158662 The discovery, biology, and drug development of sialyl Lea and sialyl Lex

Magnani, JL

Arch. Biochem. Biophys. 2004
Catalyst Activity

alpha-(1->3)-fucosyltransferase activity of FUT3 [Golgi membrane]

Orthologous Events
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