FUT3 transfers Fuc to Type 1 MSGG to form sLeA

Stable Identifier
R-HSA-9605609
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The FUT3 gene (originally named the Le gene) expresses galactoside 3(4)-L-fucosyltransferase present on the Golgi membrane. FUT3 catalyses the α1,4 and α1,3 addition of fucose to Type 1 and Type 2 oligosaccharide chains respectively, thereby playing a role in Lewis blood group determination (Kukowska-Latallo et al. 1990). Here, the addition of fucose to the subterminal N-acetylglucosaminyl (GlcNAc) residue of Type 1 monosialylgalactosylgloboside (Type 1 MSGG) in an α1,4 linkage forms the sialyl Lewis A antigen (sLeA), also known as the CA19-9 antigen, the most common tumour marker used primarily in the management of pancreatic and gastrointestinal cancers worldwide (Magnani 2004). If CA19-9 is initially elevated in pancreatic cancer, it may be requested several times during cancer treatment to monitor response and, on a regular basis following treatment, to help detect recurrence of the cancer.

Literature References
PubMed ID Title Journal Year
15158662 The discovery, biology, and drug development of sialyl Lea and sialyl Lex

Magnani, JL

Arch. Biochem. Biophys. 2004
1977660 A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase

Kukowska-Latallo, JF, Larsen, RD, Nair, RP, Lowe, JB

Genes Dev. 1990
Participants
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Catalyst Activity
Catalyst Activity
Title
alpha-(1->3)-fucosyltransferase activity of FUT3 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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