NOTCH4 binds SMAD3

Stable Identifier
R-HSA-9605414
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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NOTCH4 binds SMAD3
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NOTCH4 intracellular domain fragment (NICD4) binds phosphorylated SMAD3 upon activation of TGF-beta signaling. (Sun et al. 2005, Grabias and Konstantopoulos 2013). NICD4 may also bind SMAD2 and SMAD4 (Sun et al. 2005). NICD4 promotes ubiquitination and proteasome-mediated degradation of SMAD3 through and unknown mechanism (Grabias and Konstantopoulos 2013) and inhibits transcription mediated by the heterotrimer of SMAD3, SMAD2 and SMAD4, thus negatively regulating TGF-beta signaling (Sun et al. 2005, Grabias and Konstantopoulos 2013).
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Event Information
Go Biological Process
negative regulation of transforming growth factor beta receptor signaling pathway (0030512)
Inferred From
Notch4 binds Smad3 (Mus musculus)
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-11)
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