NR1H3 mRNA is translated

Stable Identifier
R-HSA-9605052
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
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NR1H3 mRNA is translated
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The liver X receptor alpha (LXRα or NR1H3) mRNA is translated to yield NR1H3 protein. MicroRNAs miR-1, miR-206 and miR-613 have been identified as negative regulators of NR1H3 expression and lipogenesis in the liver (Zhong D et al. 2013; Ou Z et al. 2011). Interestingly, miR-206 also regulates NR1H3 in macrophages but in an opposing manner relative to liver (Vinod M et al. 2014). Stably overexpressing miR-206 in THP-1 human macrophages revealed an up-regulation of NR1H3 and miR-206 knockdown led to a down-regulation of NR1H3 and its target genes (Vinod M et al. 2014).

Literature References
PubMed ID Title Journal Year
23496987 MicroRNA-613 represses lipogenesis in HepG2 cells by downregulating LXRα

Zhong, D, He, FT, Hu, CJ, Gao, M, Zhang, Y, Wu, GZ, Zeng, YJ, Huang, G

Lipids Health Dis 2013
21310851 MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation

Xie, W, Li, S, Gramignoli, R, Ou, Z, Strom, SC, Huang, M, Wada, T

Mol. Endocrinol. 2011
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This event is regulated
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Regulator
NR1H3 mRNA:miR-613 RISC [cytosol] (Homo sapiens)
Authored
Shamovsky, V  (2018-01-18)
Reviewed
D'Eustachio, P  (2018-12-29)
Repa, JJ  (2019-08-09)
Cummins, CL  (2019-08-09)
Created
Shamovsky, V  (2018-04-06)
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