Reactome | NR1H3 mRNA is translated

NR1H3 mRNA is translated

Stable Identifier

R-HSA-9605052

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

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The liver X receptor alpha (LXRα or NR1H3) mRNA is translated to yield NR1H3 protein. MicroRNAs miR-1, miR-206 and miR-613 have been identified as negative regulators of NR1H3 expression and lipogenesis in the liver (Zhong D et al. 2013; Ou Z et al. 2011). Interestingly, miR-206 also regulates NR1H3 in macrophages but in an opposing manner relative to liver (Vinod M et al. 2014). Stably overexpressing miR-206 in THP-1 human macrophages revealed an up-regulation of NR1H3 and miR-206 knockdown led to a down-regulation of NR1H3 and its target genes (Vinod M et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
21310851	MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation Ou, Z, Wada, T, Gramignoli, R, Li, S, Strom, SC, Huang, M, Xie, W	Mol. Endocrinol.	2011
23496987	MicroRNA-613 represses lipogenesis in HepG2 cells by downregulating LXRα Zhong, D, Zhang, Y, Zeng, YJ, Gao, M, Wu, GZ, Hu, CJ, Huang, G, He, FT	Lipids Health Dis	2013