The liver X receptor alpha (LXRα or NR1H3) mRNA is translated to yield NR1H3 protein. MicroRNAs miR-1, miR-206 and miR-613 have been identified as negative regulators of NR1H3 expression and lipogenesis in the liver (Zhong D et al. 2013; Ou Z et al. 2011). Interestingly, miR-206 also regulates NR1H3 in macrophages but in an opposing manner relative to liver (Vinod M et al. 2014). Stably overexpressing miR-206 in THP-1 human macrophages revealed an up-regulation of NR1H3 and miR-206 knockdown led to a down-regulation of NR1H3 and its target genes (Vinod M et al. 2014).
Zhong, D, He, FT, Hu, CJ, Gao, M, Zhang, Y, Wu, GZ, Zeng, YJ, Huang, G
Xie, W, Li, S, Gramignoli, R, Ou, Z, Strom, SC, Huang, M, Wada, T
© 2023 Reactome
