SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters

Stable Identifier
R-HSA-9604834
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters
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Based on studies in mice, histone deacetylase SIRT6 binds to histone H3 acetylated on lysine residue 10 (H3K9Ac epigenetic mark) at promoters of NOTCH1 and NOTCH4 genes (Liu et al. 2017).

Participants
Input
Output
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as an event of
Event Information
Go Biological Process
negative regulation of gene expression (0010629)
Inferred From
Sirt6 binds to acetylated histones at Notch1 and Notch4 gene promoters (Mus musculus)
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-05)
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