NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6

Stable Identifier
R-HSA-9604831
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6
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Based on studies in mice, SIRT6-mediated deacetylation of lysine residue 10 of H3 histones (removal of H3K9Ac epigenetic mark) at promoters of NOTCH1 and NOTCH4 genes inhibits transcription of NOTCH1 and NOTCH4. SIRT6-mediated downregulation of NOTCH1 and NOTCH4 may protect podocytes, kidney cells involved in blood filtering, from injury. SIRT6 is downregulated in podocytes of patients with podocytopathies, such as proteinuric kidney disease, and SIRT6 levels correlate with glomerular filtration rate (Liu et al. 2017).
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Output
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as an event of
Event Information
Go Biological Process
negative regulation of gene expression (0010629)
This event is regulated
Negatively by
Regulator
SIRT6:Nucleosome:NOTCH1,NOTCH4 gene [nucleoplasm] (Homo sapiens)
Active Unit
SIRT6 [nucleoplasm]
Inferred From
Notch1 and Notch4 gene transcription is inhibited by Sirt6 (Mus musculus)
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-05)
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