SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters

Stable Identifier
R-HSA-9604829
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters
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Based on studies in mice, SIRT6 deacetylates H3 histones on lysine residue 10 (removing the H3K9Ac epigenetic mark) at promoters of NOTCH1 and NOTCH4 genes (Liu et al. 2017).
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
negative regulation of gene expression (0010629)
Catalyst Activity

histone H3K9 deacetylase activity, NAD-dependent of SIRT6:Nucleosome(H3K9ac):NOTCH1,NOTCH4 gene [nucleoplasm]

Physical Entity
SIRT6:Nucleosome(H3K9ac):NOTCH1,NOTCH4 gene [nucleoplasm] (Homo sapiens)
Activity
histone H3K9 deacetylase activity, NAD-dependent (GO:0046969)
Inferred From
Sirt6 deacetylates histones at Notch1 and Notch4 gene promoters (Mus musculus)
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-05)
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