Reactome | ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4

ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4

Stable Identifier

R-HSA-9604664

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

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ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4

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ACTA2 gene, encoding smooth muscle alpha actin, possesses several RBPJ (CSL) response elements in its promoter region. Transcription of ACTA2 is positively regulated by NOTCH1, NOTCH2 and NOTCH4 (Tang et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18239137	Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site Liaw, L, Tang, Y, Urs, S	Circ. Res.	2008