Proteasome degrades ubiquitinated NICD4

Stable Identifier
R-HSA-9604642
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
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FBXW7-mediated ubiquitination targets NICD4 (NOTCH4 intracellular domain fragment) for proteasome-mediated degradation (Wu et al. 2001).

Participants
Participates
Catalyst Activity

endopeptidase activity of 26S proteasome [nucleoplasm]

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