Proteasome degrades ubiquitinated NICD4

Stable Identifier
R-HSA-9604642
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Proteasome degrades ubiquitinated NICD4
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
FBXW7-mediated ubiquitination targets NICD4 (NOTCH4 intracellular domain fragment) for proteasome-mediated degradation (Wu et al. 2001).
Participants
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Output
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as an event of
Catalyst Activity

endopeptidase activity of 26S proteasome [nucleoplasm]

Physical Entity
26S proteasome [nucleoplasm] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Inferred From
Proteasome degrades ubiquitinated mouse NICD4 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-04)
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