FBXW7 promotes ubiquitination of p-NICD4

Stable Identifier
R-HSA-9604629
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
FBXW7 promotes ubiquitination of p-NICD4
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The E3 ubiquitin ligase FBXW7, a component of the SCF ubiquitin ligase complex, binds to and ubiquitinates phosphorylated NICD4 (NOTCH4 intracellular domain fragment), targeting it for proteasome-mediated degradation (Wu et al. 2001). The level of NICD4 is significantly increased in Fbxw7 knockout mouse embryos, which die in utero and have impaired development of the vascular system (Tsunematsu et al. 2004). Notch4 level also increases when Fbxw7 is downregulated by RNA in mouse embryonic fibroblasts (Mao et al. 2004).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin protein ligase activity of FBXW7:SKP1:CUL1:RBX1 [nucleoplasm]

Physical Entity
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Inferred From
FBXW7 promotes ubiquitination of mouse p-NICD4 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-04)
Cite Us!