HEY2 gene expression is stimulated by NOTCH4

Stable Identifier
Reaction [omitted]
Homo sapiens
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Increased NOTCH4 levels and activity correlate with increased HEY2 gene expression (Bargo et al. 2010, Simoes et al. 2015, Bonyadi Rad et al. 2016).

Literature References
PubMed ID Title Journal Year
26387946 Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity

Sims, AH, Brennan, K, Howell, SJ, Yu, L, Ucar, A, Alférez, DG, Gandhi, A, Farnie, G, Gee, J, Silva, A, Howell, A, Rydén, L, Clarke, RB, Catalano, S, Santiago-Gómez, A, Landberg, G, Marangoni, E, Eyre, R, Simões, BM, Spence, K, Chemi, F, O'Brien, CS, Andó, S, Acar, A, Sarmiento-Castro, A

Cell Rep 2015
26801977 Notch4 Signaling Induces a Mesenchymal-Epithelial-like Transition in Melanoma Cells to Suppress Malignant Behaviors

Bonyadi Rad, E, Bergler, H, Hafner, C, Hammerlindl, H, Ravindran Menon, D, Schaider, H, Herlyn, M, Popper, U, Breiteneder, H, Wels, C, Kitzwoegerer, M

Cancer Res. 2016
20804727 Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats

Bargo, S, Shu, Y, Callahan, R, Plant, J, Raafat, A, McCurdy, D, Vonderhaar, BK, Amirjazil, I, Traicoff, J

Biochem. Biophys. Res. Commun. 2010
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