HEY1 gene expression is stimulated by NOTCH4

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Increased NOTCH4 levels correlate with increased HEY1 gene expression (Tsunematsu et al. 2004, Simoes et al. 2015, Bonyadi Rad et al. 2016, Fukusumi et al. 2018). NOTCH4-mediated upregulation of HEY1 in head and neck squamous cell carcinoma (HNSCC) is associated with epithelial-to-mesenchymal transition (EMT) phenotype (Fukusumi et al. 2018). In melanoma, however, HEY1 and HEY2 expression downstream of NOTCH4 is associated with mesenchymal-to-epithelial-like transition and reduced invasiveness (Bonyadi Rad et al. 2016).

Literature References
PubMed ID Title Journal Year
14672936 Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development

Tsunematsu, R, Oike, Y, Bessho, Y, Hatakeyama, S, Nakayama, KI, Suda, T, Nakayama, K, Kageyama, R, Ishida, N, Nishiyama, M

J. Biol. Chem. 2004
26387946 Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity

Sims, AH, Brennan, K, Howell, SJ, Yu, L, Ucar, A, Alférez, DG, Gandhi, A, Farnie, G, Gee, J, Silva, A, Howell, A, Rydén, L, Clarke, RB, Catalano, S, Santiago-Gómez, A, Landberg, G, Marangoni, E, Eyre, R, Simões, BM, Spence, K, Chemi, F, O'Brien, CS, Andó, S, Acar, A, Sarmiento-Castro, A

Cell Rep 2015
26801977 Notch4 Signaling Induces a Mesenchymal-Epithelial-like Transition in Melanoma Cells to Suppress Malignant Behaviors

Bonyadi Rad, E, Bergler, H, Hafner, C, Hammerlindl, H, Ravindran Menon, D, Schaider, H, Herlyn, M, Popper, U, Breiteneder, H, Wels, C, Kitzwoegerer, M

Cancer Res. 2016
29146722 The NOTCH4-HEY1 Pathway Induces Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma

Gutkind, JS, Sakai, A, Liu, C, Guo, TW, Califano, JA, Fukusumi, T, Haft, S, Ando, M, Ren, S, Amornphimoltham, P

Clin. Cancer Res. 2018
Event Information
This event is regulated