p-4S-NICD4 binds YWHAZ

Stable Identifier
R-HSA-9604387
Type
Reaction [binding]
Species
Homo sapiens
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AKT1-mediated phosphorylation of NOTCH4 intracellular domain fragment NICD4 leads to binding of NICD4 to 14-3-3-zeta (YWHAZ). Binding to YWHAZ sequesters NICD4 to the cytosol, preventing its trafficking to the nucleus, and thus negatively regulates NOTCH4 signaling (Ramakrishnan et al. 2015).

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