Reactome | B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain

B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain

Stable Identifier

R-HSA-9603989

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

ReviewStatus

5/5

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B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain

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The family of beta-1,3-galactosyltransferases (B3GALTs) transfer galactose (Gal) from UDP-alpha-D-galactose (UDP-Gal) to the β1,3 position of substrates with a terminal beta-N-acetylglucosamine (β-GlcNAc) residue. B3GALTs are involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Here, five members of this family (B3GALT1-5) can mediate the transfer of Gal to GlcNAc-β1,3-Gal-R, the precursor to blood group Type 1 oligosaccharide chains found in bodily secretions (Amado et al. 1998, Isshiki et al. 1999; review Hennet 2002).

Literature References

PubMed ID	Title	Journal	Year
12222957	The galactosyltransferase family Hennet, T	Cell. Mol. Life Sci.	2002
10212226	Cloning, expression, and characterization of a novel UDP-galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom Kudo, T, Kubota, T, Togayachi, A, Andoh, T, Watanabe, M, Sasaki, K, Shiraishi, N, Narimatsu, H, Isshiki, S, Kitajima, M, Nishihara, S	J. Biol. Chem.	1999
9582303	A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family Holmes, EH, Almeida, R, Bennett, EP, Nomoto, M, Amado, M, Hassan, H, Carneiro, F, Schwientek, T, Hollingsworth, MA, Nielsen, PA, Levery, SB, Clausen, H	J Biol Chem	1998