The family of beta-1,3-galactosyltransferases (B3GALTs) transfer galactose (Gal) from UDP-alpha-D-galactose (UDP-Gal) to the β1,3 position of substrates with a terminal beta-N-acetylglucosamine (β-GlcNAc) residue. B3GALTs are involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Here, five members of this family (B3GALT1-5) can mediate the transfer of Gal to GlcNAc-β1,3-Gal-R, the precursor to blood group Type 1 oligosaccharide chains found in bodily secretions (Amado et al. 1998, Isshiki et al. 1999; review Hennet 2002).
Hennet, T
Kudo, T, Kubota, T, Togayachi, A, Andoh, T, Watanabe, M, Sasaki, K, Shiraishi, N, Narimatsu, H, Isshiki, S, Kitajima, M, Nishihara, S
Holmes, EH, Almeida, R, Bennett, EP, Nomoto, M, Amado, M, Hassan, H, Carneiro, F, Schwientek, T, Hollingsworth, MA, Nielsen, PA, Levery, SB, Clausen, H
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity of B3GALTs [Golgi membrane]
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