B3GALTs transfer Gal to GlcNAc-β1,3-Gal-R to form Type 1 chain

Stable Identifier
Reaction [transition]
Homo sapiens
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The family of beta-1,3-galactosyltransferases (B3GALTs) transfer galactose (Gal) from UDP-alpha-D-galactose (UDP-Gal) to the β1,3 position of substrates with a terminal beta-N-acetylglucosamine (β-GlcNAc) residue. B3GALTs are involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Here, five members of this family (B3GALT1-5) can mediate the transfer of Gal to GlcNAc-β1,3-Gal-R, the precursor to blood group Type 1 oligosaccharide chains found in bodily secretions (Amado et al. 1998, Isshiki et al. 1999; review Hennet 2002).

Literature References
PubMed ID Title Journal Year
12222957 The galactosyltransferase family

Hennet, T

Cell. Mol. Life Sci. 2002
10212226 Cloning, expression, and characterization of a novel UDP-galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom

Kudo, T, Kubota, T, Togayachi, A, Andoh, T, Watanabe, M, Sasaki, K, Shiraishi, N, Narimatsu, H, Isshiki, S, Kitajima, M, Nishihara, S

J. Biol. Chem. 1999
9582303 A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family

Holmes, EH, Almeida, R, Bennett, EP, Nomoto, M, Amado, M, Hassan, H, Carneiro, F, Schwientek, T, Hollingsworth, MA, Nielsen, PA, Levery, SB, Clausen, H

J Biol Chem 1998
Catalyst Activity

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity of B3GALTs [Golgi membrane]

Orthologous Events
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