ST3GAL3 transfers Neu5Ac to Type 1 chain to form Type 1 MSGG

Stable Identifier
R-HSA-9603987
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (ST3GAL3), located on the Golgi membrane, mediates the transfer of sialic acid (Neu5Ac, N-acetylneuraminic acid) in an α2,3 linkage to the terminal galactose of Gal-beta-1,3-GlcNAc- and Gal-beta-1,4-GalNAc- sequences found on glycoproteins and glycolipids (Kitagawa & Paulson 1993). The product, Type 1 monosialylgalactosylgloboside (Type 1 MSGG) is the precursor to sialyl Lewis a (sLeA) (also known as the CA19-9 antigen), a tumour marker that is used primarily in the management of pancreatic cancer. Increased sialylation has been observed to be associated with malignant transformation and metastasis.

Literature References
PubMed ID Title Journal Year
8333853 Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase

Kitagawa, H, Paulson, JC

Biochem Biophys Res Commun 1993
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity of ST3GAL3 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created