FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Analogous to FUT3 adding fucose to Type 1 chains to form LeA, alpha-(1,3)-fucosyltransferases 4, 5 and 9 (FUT4,5,9), resident on the Golgi membrane, mediate the transfer of fucose (Fuc) to Type 2 oligosaccharide chains in an α1,3 linkage to form the Lewis X antigen (LeX) (Goelz et al. 1990, Lowe et al. 1991, Weston et al. 1992, Toivonen et al. 2002). FUT10 and FUT11 also exhibit α1,3 fucosyltransferase activity (Mollicone et al. 2009).

Literature References
PubMed ID Title Journal Year
1716630 Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion

Larsen, RD, Macher, BA, Kelly, RJ, Lowe, JB, Marks, RM, Kukowska-Latallo, JF, Ernst, LK, Nair, RP

J. Biol. Chem. 1991
19088067 Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11)

Garcia-Rosasco, M, Martinez-Duncker, I, Oriol, R, Mollicone, R, Candelier, JJ, Moore, SE, Bovin, N

J. Biol. Chem. 2009
1702034 ELFT: a gene that directs the expression of an ELAM-1 ligand

Newman, B, Lobb, R, Chi-Rosso, G, Hession, C, Goff, D, Tizard, R, Goelz, SE, Griffiths, B

Cell 1990
12107078 Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile

Nishihara, S, Renkonen, R, Toivonen, S, Narimatsu, H, Renkonen, O

Glycobiology 2002
1740457 Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities

Larsen, RD, Weston, BW, Lowe, JB, Nair, RP

J. Biol. Chem. 1992
Catalyst Activity

alpha-(1->3)-fucosyltransferase activity of FUT4,5,9(10,11) [Golgi membrane]

Orthologous Events
Cite Us!