Reactome | FUT4,5,9 transfer Fuc to Type 2 chains to form LeX

FUT4,5,9 transfer Fuc to Type 2 chains to form LeX

Stable Identifier

R-HSA-9603984

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

ReviewStatus

5/5

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FUT4,5,9 transfer Fuc to Type 2 chains to form LeX

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Analogous to FUT3 adding fucose to Type 1 chains to form LeA, alpha-(1,3)-fucosyltransferases 4, 5 and 9 (FUT4,5,9), resident on the Golgi membrane, mediate the transfer of fucose (Fuc) to Type 2 oligosaccharide chains in an α1,3 linkage to form the Lewis X antigen (LeX) (Goelz et al. 1990, Lowe et al. 1991, Weston et al. 1992, Toivonen et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
1716630	Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion Lowe, JB, Kukowska-Latallo, JF, Nair, RP, Larsen, RD, Marks, RM, Macher, BA, Kelly, RJ, Ernst, LK	J. Biol. Chem.	1991
1702034	ELFT: a gene that directs the expression of an ELAM-1 ligand Goelz, SE, Hession, C, Goff, D, Griffiths, B, Tizard, R, Newman, B, Chi-Rosso, G, Lobb, R	Cell	1990
12107078	Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile Toivonen, S, Nishihara, S, Narimatsu, H, Renkonen, O, Renkonen, R	Glycobiology	2002
1740457	Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities Weston, BW, Nair, RP, Larsen, RD, Lowe, JB	J. Biol. Chem.	1992