Analogous to FUT3 adding fucose to Type 1 chains to form LeA, alpha-(1,3)-fucosyltransferases 4, 5 and 9 (FUT4,5,9), resident on the Golgi membrane, mediate the transfer of fucose (Fuc) to Type 2 oligosaccharide chains in an α1,3 linkage to form the Lewis X antigen (LeX) (Goelz et al. 1990, Lowe et al. 1991, Weston et al. 1992, Toivonen et al. 2002). FUT10 and FUT11 also exhibit α1,3 fucosyltransferase activity (Mollicone et al. 2009).
Larsen, RD, Macher, BA, Kelly, RJ, Lowe, JB, Marks, RM, Kukowska-Latallo, JF, Ernst, LK, Nair, RP
Garcia-Rosasco, M, Martinez-Duncker, I, Oriol, R, Mollicone, R, Candelier, JJ, Moore, SE, Bovin, N
Newman, B, Lobb, R, Chi-Rosso, G, Hession, C, Goff, D, Tizard, R, Goelz, SE, Griffiths, B
Nishihara, S, Renkonen, R, Toivonen, S, Narimatsu, H, Renkonen, O
Larsen, RD, Weston, BW, Lowe, JB, Nair, RP
alpha-(1->3)-fucosyltransferase activity of FUT4,5,9(10,11) [Golgi membrane]
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