Reactome | FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX

FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX

Stable Identifier

R-HSA-9603984

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen, Golgi membrane

ReviewStatus

5/5

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FUT4,5,9,(10,11) transfer Fuc to Type 2 chains to form LeX

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Analogous to FUT3 adding fucose to Type 1 chains to form LeA, alpha-(1,3)-fucosyltransferases 4, 5 and 9 (FUT4,5,9), resident on the Golgi membrane, mediate the transfer of fucose (Fuc) to Type 2 oligosaccharide chains in an α1,3 linkage to form the Lewis X antigen (LeX) (Goelz et al. 1990, Lowe et al. 1991, Weston et al. 1992, Toivonen et al. 2002). FUT10 and FUT11 also exhibit α1,3 fucosyltransferase activity (Mollicone et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
1716630	Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion Larsen, RD, Macher, BA, Kelly, RJ, Lowe, JB, Marks, RM, Kukowska-Latallo, JF, Ernst, LK, Nair, RP	J. Biol. Chem.	1991
19088067	Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11) Garcia-Rosasco, M, Martinez-Duncker, I, Oriol, R, Mollicone, R, Candelier, JJ, Moore, SE, Bovin, N	J. Biol. Chem.	2009
1702034	ELFT: a gene that directs the expression of an ELAM-1 ligand Newman, B, Lobb, R, Chi-Rosso, G, Hession, C, Goff, D, Tizard, R, Goelz, SE, Griffiths, B	Cell	1990
12107078	Fuc-TIX: a versatile alpha1,3-fucosyltransferase with a distinct acceptor- and site-specificity profile Nishihara, S, Renkonen, R, Toivonen, S, Narimatsu, H, Renkonen, O	Glycobiology	2002
1740457	Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities Larsen, RD, Weston, BW, Lowe, JB, Nair, RP	J. Biol. Chem.	1992